2,4-Diaryl Benzofuro[3,2-b]pyridine Derivatives: Design, Synthesis, and Evaluation of Topoisomerase Inhibitory Activity and Cytotoxicity

Title
2,4-Diaryl Benzofuro[3,2-b]pyridine Derivatives: Design, Synthesis, and Evaluation of Topoisomerase Inhibitory Activity and Cytotoxicity
Author(s)
프리텀다빠장영동박필훈지준구[지준구]권영주[권영주]이응석
Keywords
DNA TOPOISOMERASES; 2,4,6-TRISUBSTITUTED PYRIDINE; QUINOLINE DERIVATIVES; I INHIBITION; TARGETS; DOCKING; MOIETY
Issue Date
201310
Publisher
KOREAN CHEMICAL SOC
Citation
BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.34, no.10, pp.3073 - 3082
Abstract
Designed and synthesized twenty-four 2,4-diaryl benzofuro[3,2-b]pyridine derivatives were evaluated for topoisomerase I and 11 inhibitory activities as well as cytotoxicities against several human cancer cell lines. Various aryl groups such as phenyl, 2- or 3- furyl, 2- or 3-thienyl, and 2-pyridyl were substituted at 2- or 4-position of central pyridine. Compounds 8, 12, 13, and 14, with 2-furyl either at 2- or 4- position of central pyridine showed the significant topoisomerase II inhibitory activity at 100 mu M.
URI
http://hdl.handle.net/YU.REPOSITORY/28826http://dx.doi.org/10.5012/bkcs.2013.34.10.3073
ISSN
0253-2964
Appears in Collections:
중앙도서관 > rims journal
약학대학 > 약학부 > Articles
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