The effect of gut microbiota on drug metabolism

Title
The effect of gut microbiota on drug metabolism
Author(s)
정태천강미정Hyung Gyun Kim[Hyung Gyun Kim]김진성오도경엄연지서채신한지원조현지김기환Hye Gwang Jeong[Hye Gwang Jeong]
Keywords
HUMAN INTESTINAL MICROFLORA; HEPG2 CELL-CULTURES; GERM-FREE RATS; IN-VITRO; BACTERIAL METABOLISM; BETA-GLUCURONIDASE; INDUCED TOXICITY; L-DOPA; ANTIALLERGIC ACTIVITIES; ANAEROBIC DEGRADATION
Issue Date
201310
Publisher
INFORMA HEALTHCARE
Citation
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, v.9, no.10, pp.1295 - 1308
Abstract
Introduction: Numerous drugs and toxicants must be metabolized to an active form. Metabolic activation by host tissues, such as the liver, has been well studied. However, drug and toxicant metabolism by the intestinal microbiota is an unexplored, but essential, field of study in pharmacology and toxicology. The taxonomic diversity and sheer numbers of the intestinal microbiota, and their capacity to metabolize xenobiotics, underscore the importance of this mode of metabolism. Areas covered: Metabolism by the intestinal microbiota has focused on the natural products of glycosides hydrolyzed by intestinal microbiota enzymes, but not by host tissues. Metabolism of synthetic drugs by the intestinal microbiota has been less-intensively investigated. This review provides an overview of xenobiotic metabolism by the intestinal microbiota of both natural products and synthetic drugs. Expert opinion: Metabolism by the intestinal microbiota might result in a different metabolite profile than that produced by host tissues. This could potentially result in either activation or inactivation of the pharmacological and/or toxicological actions of the compound in question. The contribution of the intestinal microbiota to drug metabolism remains relatively unexplored. Therefore, studies of xenobiotic metabolism by the intestinal microbiota need to be included in new drug development as well as classical studies of host tissue metabolism.
URI
http://hdl.handle.net/YU.REPOSITORY/28824http://dx.doi.org/10.1517/17425255.2013.807798
ISSN
1742-5255
Appears in Collections:
약학대학 > 약학부 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE