Sauchinone, a lignan from Saururus chinensis, attenuates neutrophil pro-inflammatory activity and acute lung injury

Title
Sauchinone, a lignan from Saururus chinensis, attenuates neutrophil pro-inflammatory activity and acute lung injury
Author(s)
손종근Hui-Jing Han[Hui-Jing Han]Mei Li[Mei Li]서창섭[서창섭]송성원[송성원]곽상현[곽상현]배홍범[배홍범]
Keywords
ACTIVATED PROTEIN-KINASE; NF-KAPPA-B; PULMONARY INFLAMMATION; SIGNAL-TRANSDUCTION; MURINE MODEL; LIPOPOLYSACCHARIDE; CELLS; MACROPHAGES; INVOLVEMENT; EXPRESSION
Issue Date
201310
Publisher
ELSEVIER SCIENCE BV
Citation
INTERNATIONAL IMMUNOPHARMACOLOGY, v.17, no.2, pp.471 - 477
Abstract
Previous studies have shown that sauchinone modulates the expression of inflammatory mediators through mitogen-activated protein kinase (MAPK) pathways in various cell types. However, little information exists about the effect of sauchinone on neutrophils, which play a crucial role in inflammatory process such as acute lung injury (ALI). We found that sauchinone decreased the phosphorylation of p38 MAPK in lipopolysaccharide (LPS)-stimulated murine bone marrow neutrophils, but not ERK1/2 and JNK. Exposure of LPS-stimulated neutrophils to sauchinone or SB203580, a p38 inhibitor, diminished production of tumor necrosis factor (TNF)-alpha and macrophage inflammatory protein (MIP)-2 compared to neutrophils cultured with LPS. Treatment with sauchinone decreased the level of phosphorylated ribosomal protein S6 (rpS6) in LPS-stimulated neutrophils. Systemic administration of sauchinone to mice led to reduced levels of phosphorylation of p38 and rpS6 in mice lungs given LPS, decreased TNF-alpha. and MIP-2 production in bronchoalveolar lavage fluid, and also diminished the severity of LPS-induced lung injury, as determined by reduced neutrophil accumulation in the lungs, wet/dry weight ratio, and histological analysis. These results suggest that sauchinone diminishes LPS-induced neutrophil activation and ALI. (C) 2013 Elsevier B.V. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/28817http://dx.doi.org/10.1016/j.intimp.2013.07.011
ISSN
1567-5769
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약학대학 > 약학부 > Articles
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