Direction of Intercalation of a bis-Ru(II) Complex to DNA Probed by a Minor Groove Binding Molecule 4 ',6-Diamidino-2-phenylindole

Title
Direction of Intercalation of a bis-Ru(II) Complex to DNA Probed by a Minor Groove Binding Molecule 4 ',6-Diamidino-2-phenylindole
Author(s)
김석규장윤정김래영프리아한성욱[한성욱]배인호
Keywords
DINUCLEAR RUTHENIUM(II) COMPLEX; METAL-COMPLEXES; LINEAR DICHROISM; LIGHT-SWITCH; ELECTRON-TRANSFER; DIPYRIDOPHENAZINE COMPLEX; MAJOR GROOVE; SPECTROSCOPY; SEQUENCE; MODES
Issue Date
201310
Publisher
KOREAN CHEMICAL SOC
Citation
BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.34, no.10, pp.2895 - 2899
Abstract
Direction of intercalation to DNA of the planar dipyrido[3,2-a:2',3'-c]phenazine ligands (dppz) of a bis-Ru(11) complex namely, [Ru(1,10-phenanthroline)(2)dipyrido[3,2-a:2',3'-c]phenazine](2+) linkered by a 1,3-bis(4-pyridyl)propane, was investigated by probing the behavior of 4',6-diamidino-2-phenylindole (DAPI) that bound deep in the minor groove. Bis-intercalation of DPPZ resulted in a little blue shift and hyperchromism in DAPI absorption band, and a large decrease in DAPI fluorescence intensity which accompined by an increase in the dppz emission intensity. Diminishing the intenisty of the positive induced circular dichroism (CD) and linear dichroism (LD) were also observed. These spectral changes indicated that insertion of dppz ligand caused the change of the binding mode of DAPI, which probably moved to the exterior of DNA from the minor groove and interacted with the phospghate groups of DNA by electrostatic interaction. At the surface of DNA, DAPI binds at the phosphate groups of DNA by electrostatic attraction. Consequently, this observation indicated that the dppz ligand intercalated from the minor groove.
URI
http://hdl.handle.net/YU.REPOSITORY/28812http://dx.doi.org/10.5012/bkcs.2013.34.10.2895
ISSN
0253-2964
Appears in Collections:
이과대학 > 화학생화학부 > Articles
문과대학 > 중국언어문화학과 > Articles
이과대학 > 물리학과 > Articles
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