Anthocyanins From Black Soybean Seed Coat Enhance Wound Healing

Title
Anthocyanins From Black Soybean Seed Coat Enhance Wound Healing
Author(s)
허지안Lianji Xu[Lianji Xu]최태현[최태현]김석화[김석화]김상현[김상현]장혁원[장혁원]조미선[조미선]권선영[권선영]신성철[신성철]Jong Il Chung[Jong Il Chung]Dawon Kang[Dawon Kang]Duo Zhang[Duo Zhang]
Keywords
INFLAMMATION; EXPRESSION; COLLAGEN; INJURY; SKIN; PIG
Issue Date
201310
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Citation
ANNALS OF PLASTIC SURGERY, v.71, no.4, pp.415 - 420
Abstract
Anthocyanins are known to have antioxidant and antiinflammatory effects. We hypothesized that anthocyanins would enhance wound healing in Sprague-Dawley rats. The purpose of this study was to evaluate our hypothesis and investigate the mechanism of wound healing enhancement. The cytoprotective effect of an immortalized epidermal keratinocyte cell line (HaCaT) and human neonatal dermal fibroblasts in response to various concentrations of anthocyanins was determined. Vascular endothelial growth factor (VEGF) and thrombospondin 1 (TSP1) of HaCaT were measured by Western blot analysis. Anthocyanins were applied to the wounds in rats, and the healing ratio was calculated. Tissue VEGF, TSP1, CD31, nuclear factor-kappa B, and phosphorylation of I kappa B alpha were measured. The viability of the HaCaT cell line and human neonatal dermal fibroblasts increased under cytotoxicity by H2O2 in the anthocyanin-treated groups. The VEGF in the anthocyanin-treated groups increased, whereas TSP1 decreased. Wounds in the experimental groups healed faster, and VEGF and CD31 increased in the experimental groups, whereas TSP1 decreased. Anthocyanins inhibited the translocation of nuclear factor-kappa B (p65) from cytosol to nucleus and also prevented the phosphorylation of I kappa B alpha. Anthocyanins enhance wound healing through a cytoprotective effect, enhancement of angiogenesis, and an antiinflammatory effect.
URI
http://hdl.handle.net/YU.REPOSITORY/28797http://dx.doi.org/10.1097/SAP.0b013e31824ca62b
ISSN
0148-7043
Appears in Collections:
의과대학 > 내과학교실 > Articles
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