Moringa Fruit Inhibits LPS-Induced NO/iNOS Expression through Suppressing the NF-kappa B Activation in RAW264.7 Cells

Title
Moringa Fruit Inhibits LPS-Induced NO/iNOS Expression through Suppressing the NF-kappa B Activation in RAW264.7 Cells
Author(s)
장현욱정윤정[정윤정]이태성[이태성]박윤엽[박윤엽]채휘건[채휘건]정일경[정일경]김철호[김철호]최윤현[최윤현]김원제[김원제]문성관[문성관]장영채[장영채]이효진[이효진]
Keywords
NITRIC-OXIDE-SYNTHASE; LIPOPOLYSACCHARIDE-INDUCED CYCLOOXYGENASE-2; MURINE MACROPHAGES; GENE-EXPRESSION; PROTEIN-KINASE; MAP KINASE; OLEIFERA; INFLAMMATION; PATHWAYS; MATRIX-METALLOPROTEINASE-9
Issue Date
201310
Publisher
WORLD SCIENTIFIC PUBL CO PTE LTD
Citation
AMERICAN JOURNAL OF CHINESE MEDICINE, v.41, no.5, pp.1109 - 1123
Abstract
In this study, we evaluated the anti-inflammatory effects of moringa (Moringa oleifera Lam.), a natural biologically active substance, by determining its inhibitory effects on pro-inflammatory mediators in lipopolysaccharide (LPS)-stimulated macrophage RAW264.7 cells. Extracts from different parts of moringa (root, leaf, and fruit) reduced LPSinduced nitric oxide (NO) release in a dose-dependent manner. The moringa fruit extract most effectively inhibited LPS-induced NO production and levels of inducible nitric oxide synthase (iNOS). The moringa fruit extract also was shown to suppress the production of inflammatory cytokines including IL-1 beta, TNF-alpha, and IL-6. Furthermore, moringa fruit extract inhibited the cytoplasmic degradation of I kappa B-alpha and the nuclear translocation of p65 proteins, resulting in lower levels of NF-kappa B transactivation. Collectively, the results of this study demonstrate that moringa fruit extract reduces the levels of pro-inflammatory mediators including NO, IL-1 beta, TNF-alpha, and IL-6 via the inhibition of NF-kappa B activation in RAW264.7 cells. These findings reveal, in part, the molecular basis underlying the anti-inflammatory properties of moringa fruit extract.
URI
http://hdl.handle.net/YU.REPOSITORY/28790http://dx.doi.org/10.1142/S0192415X13500754
ISSN
0192-415X
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약학대학 > 약학부 > Articles
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