Synthesis, characterization, DNA interaction, antioxidant and anticancer activity of new ruthenium(II) complexes of thiosemicarbazone/semicarbazone bearing 9,10-phenanthrenequinone

Title
Synthesis, characterization, DNA interaction, antioxidant and anticancer activity of new ruthenium(II) complexes of thiosemicarbazone/semicarbazone bearing 9,10-phenanthrenequinone
Author(s)
장윤정Panneerselvam Anitha[Panneerselvam Anitha]Nataraj Chitrapriya[Nataraj Chitrapriya]Periasamy Viswanathamurthi[Periasamy Viswanathamurthi]
Keywords
TRANSITION-METAL-COMPLEXES; IN-VITRO; BIOLOGICAL-ACTIVITY; NAPHTHAQUINONE THIOSEMICARBAZONE; ISOLATED HEPATOCYTES; SPECTRAL PROPERTIES; CATALYTIC-ACTIVITY; CRYSTAL-STRUCTURE; ETHIDIUM-BROMIDE; BINDING
Issue Date
201310
Publisher
ELSEVIER SCIENCE SA
Citation
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, v.129, pp.17 - 26
Abstract
A new series of octahedral ruthenium(II) complexes supported by tridentate ligands derived from phenanthrenequinone and derivatives of thiosemicarbazide/semicarbazide and other co-ligands have been synthesized and characterized. DNA binding experiments indicated that ruthenium(II) complexes can interact with DNA through non-intercalation and the apparent binding constant value (K-b) of [RuCl(CO)(PPh3)(L-3)] (3) at room temperature was calculated to be 2.27 x 10(3) M-1. The DNA cleavage studies showed that the complexes have better cleavage of pBR 322 DNA. Antioxidative activity proved that the complexes have significant radical scavenging activity against free radicals. Cytotoxic activities showed that the ruthenium(II) complexes exhibited more effective cytotoxic activity against selected cancer cells. (C) 2013 Elsevier B.V. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/28779http://dx.doi.org/10.1016/j.jphotobiol.2013.09.005
ISSN
1011-1344
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문과대학 > 중국언어문화학과 > Articles
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