7-fluoroindole as an antivirulence compound against Pseudomonas aeruginosa

Title
7-fluoroindole as an antivirulence compound against Pseudomonas aeruginosa
Author(s)
이진태조무환김정애이진형김용규
Keywords
QUORUM-SENSING INHIBITORS; BIOFILM FORMATION; ESCHERICHIA-COLI; VIRULENCE FACTORS; SWARMING MOTILITY; RESISTANCE; MECHANISMS; INDOLE; SIGNAL; GENES
Issue Date
201204
Publisher
WILEY-BLACKWELL
Citation
FEMS MICROBIOLOGY LETTERS, v.329, no.1, pp.36 - 44
Abstract
The emergence of antibiotic resistance has necessitated new therapeutic approaches for combating persistent bacterial infection. An alternative approach is regulation of bacterial virulence instead of growth suppression, which can readily lead to drug resistance. The virulence of the opportunistic human pathogen Pseudomonas aeruginosa depends on a large number of extracellular factors and biofilm formation. Thirty-one natural and synthetic indole derivatives were screened. 7-fluoroindole (7FI) was identified as a compound that inhibits biofilm formation and blood hemolysis without inhibiting the growth of planktonic P.similar to aeruginosa cells. Moreover, 7FI markedly reduced the production of quorum-sensing (QS)-regulated virulence factors 2-heptyl-3-hydroxy-4(1H)-quinolone, pyocyanin, rhamnolipid, two siderophores, pyoverdine and pyochelin. 7FI clearly suppressed swarming motility, protease activity and the production of a polymeric matrix in P.similar to aeruginosa. However, unlike natural indole compounds, synthetic 7FI did not increase antibiotic resistance. Therefore, 7FI is a potential candidate for use in an antivirulence approach against persistent P.similar to aeruginosa infection.
URI
http://hdl.handle.net/YU.REPOSITORY/28668http://dx.doi.org/10.1111/j.1574-6968.2012.02500.x
ISSN
0378-1097
Appears in Collections:
공과대학 > 화학공학부 > Articles
약학대학 > 약학부 > Articles
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