Sterols from a soft coral, Dendronephthya gigantea as farnesoid X-activated receptor antagonists

Title
Sterols from a soft coral, Dendronephthya gigantea as farnesoid X-activated receptor antagonists
Author(s)
최혁재Kyoungjin Shin[Kyoungjin Shin]Jungwook Chin[Jungwook Chin]Dongyup Hahn[Dongyup Hahn]Jaehwan Lee[Jaehwan Lee]Hoosang Hwang[Hoosang Hwang]Dong Hwan Won[Dong Hwan Won]Jungyeob Ham[Jungyeob Ham]Ensoo Kang[Ensoo Kang]Hiyoung Kim[Hiyoung Kim]Moon Kyeong Ju[Moon Kyeong Ju]Sang-Jip Nam[Sang-Jip Nam]Heonjoong Kang[Heonjoong Kang]
Keywords
STRUCTURE ELUCIDATION; URSODEOXYCHOLIC ACID
Issue Date
201204
Publisher
ELSEVIER SCIENCE INC
Citation
STEROIDS, v.77, no.5, pp.355 - 359
Abstract
Three new steroids 3-oxocholest-1,22-dien-12 beta-ol (1), 3-oxocholest-1,4-dien-20 beta-ol (2), 3-oxocholest-1,4-dien-12 beta-ol (3), and three known steroids (20S)-20-Hydroxyergosta-1,4,24(28)-trien-3-one (4)[7a], 5 alpha,8 alpha-Epidioxycholesta-6,22-dien-3 beta-ol (5) [10] and 5-cholestene-3 beta,12 beta-diol (6) 1111 were isolated from a soft coral Dendronephthya gigantea. Their chemical structures and relative stereochemistry were elucidated by the analysis of HRMS and 2-D NMR spectroscopic data. The steroids 1 and 2 showed notable inhibitory activity against farnesoid X-activated receptor (FXR) with IC50's 14 and 15 mu M. (C) 2012 Elsevier Inc. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/28656http://dx.doi.org/10.1016/j.steroids.2011.12.027
ISSN
0039-128X
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약학대학 > 약학부 > Articles
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