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dc.contributor.author이진태ko
dc.contributor.author조무환ko
dc.contributor.author박주현[박주현]ko
dc.contributor.author이진형ko
dc.contributor.author김창진[김창진]ko
dc.contributor.author이재찬[이재찬]ko
dc.date.accessioned2015-12-17T02:34:09Z-
dc.date.available2015-12-17T02:34:09Z-
dc.date.created2015-11-13-
dc.date.issued201204-
dc.identifier.citationBIOTECHNOLOGY LETTERS, v.34, no.4, pp.655 - 661-
dc.identifier.issn0141-5492-
dc.identifier.urihttp://hdl.handle.net/YU.REPOSITORY/28644-
dc.identifier.urihttp://dx.doi.org/10.1007/s10529-011-0825-z-
dc.description.abstractBacterial biofilms are associated with chronic infections due to their resistance to antimicrobial agents. Staphylococcus aureus is a versatile human pathogen and can form biofilms on human tissues and diverse medical devices. To identify novel biofilm inhibitors of S. aureus, the supernatants from a library of 458 Actinomycetes strains were screened. The culture supernatants (1% v/v) of more than 10 Actinomycetes strains inhibited S. aureus biofilm formation by more than 80% without affecting the growth. The culture supernatants of these biofilm-reducing Actinomycetes strains contained a protease (equivalent to 0.1 mu g proteinase K ml(-1)), which both inhibited S. aureus biofilm formation and detached pre-existing S. aureus biofilms. This study suggests that protease treatment could be a feasible tool to reduce and eradicate S. aureus biofilms.-
dc.language영어-
dc.publisherSPRINGER-
dc.subjectEPIDERMIDIS-
dc.subjectINFECTIONS-
dc.subjectRESISTANCE-
dc.subjectBACTERIA-
dc.titleExtracellular protease in Actinomycetes culture supernatants inhibits and detaches Staphylococcus aureus biofilm formation-
dc.typeArticle-
dc.identifier.wosid000301295900009-
dc.identifier.scopusid2-s2.0-84858005268-
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공과대학 > 화학공학부 > Articles
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