Extracellular protease in Actinomycetes culture supernatants inhibits and detaches Staphylococcus aureus biofilm formation

Title
Extracellular protease in Actinomycetes culture supernatants inhibits and detaches Staphylococcus aureus biofilm formation
Author(s)
이진태조무환박주현[박주현]이진형김창진[김창진]이재찬[이재찬]
Keywords
EPIDERMIDIS; INFECTIONS; RESISTANCE; BACTERIA
Issue Date
201204
Publisher
SPRINGER
Citation
BIOTECHNOLOGY LETTERS, v.34, no.4, pp.655 - 661
Abstract
Bacterial biofilms are associated with chronic infections due to their resistance to antimicrobial agents. Staphylococcus aureus is a versatile human pathogen and can form biofilms on human tissues and diverse medical devices. To identify novel biofilm inhibitors of S. aureus, the supernatants from a library of 458 Actinomycetes strains were screened. The culture supernatants (1% v/v) of more than 10 Actinomycetes strains inhibited S. aureus biofilm formation by more than 80% without affecting the growth. The culture supernatants of these biofilm-reducing Actinomycetes strains contained a protease (equivalent to 0.1 mu g proteinase K ml(-1)), which both inhibited S. aureus biofilm formation and detached pre-existing S. aureus biofilms. This study suggests that protease treatment could be a feasible tool to reduce and eradicate S. aureus biofilms.
URI
http://hdl.handle.net/YU.REPOSITORY/28644http://dx.doi.org/10.1007/s10529-011-0825-z
ISSN
0141-5492
Appears in Collections:
공과대학 > 화학공학부 > Articles
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