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dc.contributor.author장현욱ko
dc.contributor.author유예ko
dc.contributor.author정용태ko
dc.contributor.author이선ko
dc.contributor.author김미진ko
dc.contributor.author박필훈ko
dc.contributor.author황승락ko
dc.contributor.author손종근ko
dc.date.accessioned2015-12-17T02:33:37Z-
dc.date.available2015-12-17T02:33:37Z-
dc.date.created2015-11-13-
dc.date.issued201311-
dc.identifier.citationBIOMOLECULES & THERAPEUTICS, v.21, no.6, pp.435 - 441-
dc.identifier.issn1976-9148-
dc.identifier.urihttp://hdl.handle.net/YU.REPOSITORY/28623-
dc.identifier.urihttp://dx.doi.org/10.4062/biomolther.2013.068-
dc.description.abstractEmodin, a naturally occurring anthraquinone derivative isolated from Polygoni cuspidati radix, has several beneficial pharmacologic effects, which include anti-cancer, anti-diabetic, and anti-inflammatory activities. In this study, the authors examined the effect of emodin on the production of proinflammatory cytokines, such as, tumor necrosis factor (TNE)-alpha and interleukin (IL)-6, in mouse bone marrow-derived mast cells (BMMCs) stimulated with phorbol 12-myristate 13-acetate (PMA) plus the calcium ionophore A23187. To investigate the mechanism responsible for the regulation of pro-inflammatory cytokine production by emodin, the authors assessed its effects on the activations of transcriptional factor nuclear factor-kappa B (NF-kappa B) and mitogen-activated protein kinases (MAPKs). Emodin attenuated the nuclear translocation of (NF)-kappa B p65 and its DNA-binding activity by reducing the phosphorylation and degradation of I kappa B alpha and the phosphorylation of I kappa B kinase B (IKK). Furthermore, emodin dose-dependently attenuated the phosphorylations of MAPKs, such as, extracellular signal-regulated kinase 1/2 (ERK1/2), p38 MAP kinase, and the stress-activated protein kinases (SAPK)/c-Jun-N-terminal kinase (JNK). Taken together, the findings of this study suggest that the anti-inflammatory effects of emodin on PMA plus A23187-stimulated BMMCs are mediated via the inhibition of NE-kappa B activation and of the MAPK pathway.-
dc.language영어-
dc.publisherKOREAN SOC APPLIED PHARMACOLOGY-
dc.subjectACTIVATED PROTEIN-KINASE-
dc.subjectPROSTAGLANDIN D-2 GENERATION-
dc.subjectHUMAN PROSTATE-CANCER-
dc.subjectTUMOR-NECROSIS-FACTOR-
dc.subjectPROINFLAMMATORY CYTOKINES-
dc.subjectINFLAMMATORY RESPONSES-
dc.subjectGENE-EXPRESSION-
dc.subjectALLERGIC-ASTHMA-
dc.subjectMURINE MODEL-
dc.subjectINVOLVEMENT-
dc.titleEmodin Isolated from Polygoni cuspidati Radix Inhibits TNF-alpha and IL-6 Release by Blockading NF-kappa B and MAP Kinase Pathways in Mast Cells Stimulated with PMA Plus A23187-
dc.typeArticle-
dc.identifier.wosid000329335800003-
dc.identifier.scopusid2-s2.0-84888783125-
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