Emodin Isolated from Polygoni cuspidati Radix Inhibits TNF-alpha and IL-6 Release by Blockading NF-kappa B and MAP Kinase Pathways in Mast Cells Stimulated with PMA Plus A23187

Title
Emodin Isolated from Polygoni cuspidati Radix Inhibits TNF-alpha and IL-6 Release by Blockading NF-kappa B and MAP Kinase Pathways in Mast Cells Stimulated with PMA Plus A23187
Author(s)
장현욱유예정용태이선김미진박필훈황승락손종근
Keywords
ACTIVATED PROTEIN-KINASE; PROSTAGLANDIN D-2 GENERATION; HUMAN PROSTATE-CANCER; TUMOR-NECROSIS-FACTOR; PROINFLAMMATORY CYTOKINES; INFLAMMATORY RESPONSES; GENE-EXPRESSION; ALLERGIC-ASTHMA; MURINE MODEL; INVOLVEMENT
Issue Date
201311
Publisher
KOREAN SOC APPLIED PHARMACOLOGY
Citation
BIOMOLECULES & THERAPEUTICS, v.21, no.6, pp.435 - 441
Abstract
Emodin, a naturally occurring anthraquinone derivative isolated from Polygoni cuspidati radix, has several beneficial pharmacologic effects, which include anti-cancer, anti-diabetic, and anti-inflammatory activities. In this study, the authors examined the effect of emodin on the production of proinflammatory cytokines, such as, tumor necrosis factor (TNE)-alpha and interleukin (IL)-6, in mouse bone marrow-derived mast cells (BMMCs) stimulated with phorbol 12-myristate 13-acetate (PMA) plus the calcium ionophore A23187. To investigate the mechanism responsible for the regulation of pro-inflammatory cytokine production by emodin, the authors assessed its effects on the activations of transcriptional factor nuclear factor-kappa B (NF-kappa B) and mitogen-activated protein kinases (MAPKs). Emodin attenuated the nuclear translocation of (NF)-kappa B p65 and its DNA-binding activity by reducing the phosphorylation and degradation of I kappa B alpha and the phosphorylation of I kappa B kinase B (IKK). Furthermore, emodin dose-dependently attenuated the phosphorylations of MAPKs, such as, extracellular signal-regulated kinase 1/2 (ERK1/2), p38 MAP kinase, and the stress-activated protein kinases (SAPK)/c-Jun-N-terminal kinase (JNK). Taken together, the findings of this study suggest that the anti-inflammatory effects of emodin on PMA plus A23187-stimulated BMMCs are mediated via the inhibition of NE-kappa B activation and of the MAPK pathway.
URI
http://hdl.handle.net/YU.REPOSITORY/28623http://dx.doi.org/10.4062/biomolther.2013.068
ISSN
1976-9148
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약학대학 > 약학부 > Articles
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