Fibroblast growth factor 2-functionalized collagen matrices for skeletal muscle tissue engineering

Title
Fibroblast growth factor 2-functionalized collagen matrices for skeletal muscle tissue engineering
Author(s)
김국현Jang, Jun-Hyeog[Jang, Jun-Hyeog]Yun, Ye-Rang[Yun, Ye-Rang]Lee, Sujin[Lee, Sujin]Jeon, Eunyi[Jeon, Eunyi]Kang, Wonmo[Kang, Wonmo]Kim, Hae-Won[Kim, Hae-Won]
Keywords
IN-VIVO; FACTOR-BETA; EXPRESSION; REGENERATION; PROTEIN; OXYGEN; MECHANISMS; ISCHEMIA; RADICALS; ADHESION
Issue Date
201204
Publisher
SPRINGER
Citation
BIOTECHNOLOGY LETTERS, v.34, no.4, pp.771 - 778
Abstract
Fibroblast growth factor 2 (FGF2) protein plays important roles in wound healing and tissue regeneration. Collagen is clinically used for wound care applications. We investigated the potential value of FGF2-functionalized collagen matrices for skeletal muscle tissue engineering. When C2C12 cells were treated with FGF2, cell adhesion increased after 3 and 5 days compared to the control (P < 0.05). Wound healing activity of FGF2 was slightly higher than the control through cell migration. Cell proliferation activity of FGF2-functionalized collagen matrices on C2C12 cells also increased. Taken together, FGF2 stimulated C2C12 myoblast growth by promoting cell adhesion, proliferation and wound healing activity after injury. The potential effect of FGF2-functionalized collagen matrices was also observed. Thus FGF2 stimulates skeletal muscle development and regeneration, thereby leading to potential utility for skeletal muscle tissue engineering.
URI
http://hdl.handle.net/YU.REPOSITORY/28617http://dx.doi.org/10.1007/s10529-011-0812-4
ISSN
0141-5492
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의과대학 > 내과학교실 > Articles
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