Fatty acid composition of beef is associated with exonic nucleotide variants of the gene encoding FASN

Title
Fatty acid composition of beef is associated with exonic nucleotide variants of the gene encoding FASN
Author(s)
여정수오동엽[오동엽]라부미[라부미]이윤석[이윤석]정의룡[정의룡]이채영[이채영]김윤영[김윤영]
Keywords
DNA POLYMORPHISMS; KOREAN CATTLE; SYNTHASE
Issue Date
201204
Publisher
SPRINGER
Citation
MOLECULAR BIOLOGY REPORTS, v.39, no.4, pp.4083 - 4090
Abstract
Genetic associations of fatty acid composition with exonic single nucleotide polymorphisms (SNPs) in the gene encoding fatty acid synthase (FASN) were examined using 513 Korean cattle. All five individual SNPs of g.12870 T > C, g.13126 T > C, g.15532 C > A, g.16907 T > C and g.17924 G > A were associated with a variety of fatty acid compositions and further with marbling score (P < 0.05). Their genotypes of CC, TT, AA, TT, and GG were associated with increased monounsaturated fatty acids and with decreased saturated fatty acids (P < 0.05). The genotypes at all the SNPs also increased marbling score (P < 0.05). Further genetic associations with fatty acid composition suggested that homozygous genotype with the haplotype of ATG at g.15532, g.16907, and g.17924 in a linkage disequilibrium block increased monounsaturated fatty acids and marbling score (P < 0.05). We concluded that the five exonic SNPs of g.12870, g.13126, g.15532, g.16907, and g.17924 in the FASN gene could change fatty acid contents. Their genotypes of CC, TT, AA, TT, and GG and haplotype of ATG at g.15532, g.16907, and g.17924 were recommended for genetic improvement of beef quality.
URI
http://hdl.handle.net/YU.REPOSITORY/28600http://dx.doi.org/10.1007/s11033-011-1190-7
ISSN
0301-4851
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생명공학부 > 생명공학부 > Articles
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