Genetic association of Phosphodiesterase 1B (PDE1B) with carcass traits in Korean cattle

Title
Genetic association of Phosphodiesterase 1B (PDE1B) with carcass traits in Korean cattle
Author(s)
여정수신성철[신성철]허재필[허재필]이채영[이채영]정의룡[정의룡]
Keywords
MEAT QUALITY TRAITS; SINGLE NUCLEOTIDE POLYMORPHISM; LEPTIN GENE; BOS-TAURUS; LOCI; TENDERNESS; IDENTIFICATION; CHROMOSOME-5; MARKERS; GROWTH
Issue Date
201204
Publisher
SPRINGER
Citation
MOLECULAR BIOLOGY REPORTS, v.39, no.4, pp.4869 - 4874
Abstract
Quantitative trait loci for fat deposition and carcass traits have been identified in the vicinity of the gene encoding phosphodiesterase 1B (PDE1B) on bovine chromosome 5. Therefore, the PDE1B gene can be considered as a positional and functional candidate gene for carcass traits in beef cattle. This study aimed to identify single nucleotide polymorphisms (SNPs) in the PDE1B gene and to evaluate their associations with carcass traits in Korean cattle. Eight SNPs, g.440T > G, g.17122A > G, g.17507A > C, g.17575A > G, g.17607T > C, g.17609C > A, g.17692C > T, and g.17707C > G, were identified in the region ranged from exon 1 to intron 6. Five of them were used for association analysis because of their availability of restriction fragment length polymorphisms. As a result, g.17122A > G in intron 3 was significantly associated with backfat thickness (BFT), and g.17507A > C in exon 5 was associated with longissimus dorsi muscle area (LMA, P < 0.05). Animals with the AG genotype of g.17122 had thicker BFT than those with the AA genotype. Animals with the AA or AC genotype of g.17507A > C had larger LMA than those with the CC genotype. We suggested the PDE1B gene as a candidate gene for carcass traits of beef cattle. Fine mapping would be required for application to marker-assisted selection.
URI
http://hdl.handle.net/YU.REPOSITORY/28593http://dx.doi.org/10.1007/s11033-011-1280-6
ISSN
0301-4851
Appears in Collections:
생명공학부 > 생명공학부 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE