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dc.contributor.author장현욱ko
dc.contributor.author정지학[정지학]ko
dc.contributor.author정윤정[정윤정]ko
dc.contributor.author조현지[조현지]ko
dc.contributor.author신재문[신재문]ko
dc.contributor.author강정한[강정한]ko
dc.contributor.author박관규[박관규]ko
dc.contributor.author박윤엽[박윤엽]ko
dc.contributor.author정일경[정일경]ko
dc.contributor.authorJunji Magae[Junji Magae]ko
dc.contributor.author강신성[강신성]ko
dc.contributor.author장영채[장영채]ko
dc.date.accessioned2015-12-17T02:32:52Z-
dc.date.available2015-12-17T02:32:52Z-
dc.date.created2015-11-13-
dc.date.issued201204-
dc.identifier.citationJOURNAL OF CELLULAR BIOCHEMISTRY, v.113, no.4, pp.1302 - 1313-
dc.identifier.issn0730-2312-
dc.identifier.urihttp://hdl.handle.net/YU.REPOSITORY/28588-
dc.identifier.urihttp://dx.doi.org/10.1002/jcb.24001-
dc.description.abstractAscochlorin, a non-toxic prenylphenol compound derived from the fungus Ascochyta viciae, has been shown recently to have anti-cancer effects on various human cancer cells. However, the precise molecular mechanism of this anti-cancer activity remains to be elucidated. Here, we investigated the effects of ascochlorin on hypoxia-inducible factor-1a (HIF-1a) and vascular endothelial growth factor (VEGF) expression in human epidermoid cervical carcinoma CaSki cells. Ascochlorin inhibited epidermal growth factor (EGF)-induced HIF-1a and VEGF expression through multiple potential mechanisms. First, ascochlorin selectively inhibited HIF-1a expression in response to EGF stimulation, but not in response to hypoxia (1% O2) or treatment with a transition metal (CoCl2). Second, ascochlorin inhibited EGF-induced ERK-1/2 activation but not AKT activation, both of which play essential roles in EGF-induced HIF-1a protein synthesis. Targeted inhibition of epidermal growth factor receptor (EGFR) expression using an EGFR-specific small interfering RNA (siRNA) diminished HIF-1a expression, which suggested that ascochlorin inhibits HIF-1a expression through suppression of EGFR activation. Finally, we showed that ascochlorin functionally abrogates in vivo tumor angiogenesis induced by EGF in a Matrigel plug assay. Our data suggest that ascochlorin inhibits EGF-mediated induction of HIF-1a expression in CaSki cells, providing a potentially new avenue of development of anti-cancer drugs that target tumor angiogenesis. J. Cell. Biochem. 113: 13021313, 2012. (c) 2011 Wiley Periodicals, Inc.-
dc.language영어-
dc.publisherWILEY-BLACKWELL-
dc.subjectINDUCIBLE FACTOR 1-ALPHA-
dc.subjectPROLYL HYDROXYLATION-
dc.subjectDOWN-REGULATION-
dc.subjectFACTOR-I-
dc.subjectC-MYC-
dc.subjectHYPOXIA-
dc.subjectHIF-1-ALPHA-
dc.subjectASCOFURANONE-
dc.subjectEXPRESSION-
dc.subjectFAMILY-
dc.titleAscochlorin inhibits growth factor-induced HIF-1a activation and tumor-angiogenesis through the suppression of EGFR/ERK/p70S6K signaling pathway in human cervical carcinoma cells-
dc.typeArticle-
dc.identifier.wosid000300719000024-
dc.identifier.scopusid2-s2.0-84863115594-
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