Autologous Adipose Tissue-Derived Stem Cells Treatment Demonstrated Favorable and Sustainable Therapeutic Effect for Crohn's Fistula

Title
Autologous Adipose Tissue-Derived Stem Cells Treatment Demonstrated Favorable and Sustainable Therapeutic Effect for Crohn's Fistula
Author(s)
정상훈이우용[이우용]유창식[유창식]박규주[박규주]조용범[조용범]윤상남[윤상남]김도순[김도순]하은주[하은주]김미형[김미형]유희원[유희원]
Keywords
COMPLEX PERIANAL FISTULAS; CLINICAL-TRIAL; STROMAL CELLS; T-CELLS; SETON TREATMENT; NITRIC-OXIDE; IN-ANO; DISEASE; INFLIXIMAB; TRANSPLANTATION
Issue Date
201311
Publisher
WILEY-BLACKWELL
Citation
STEM CELLS, v.31, no.11, pp.2575 - 2581
Abstract
Fistula is a representative devastating complication in Crohn's patients due to refractory to conventional therapy and high recurrence. In our phase I clinical trial, adipose tissue-derived stem cells (ASCs) demonstrated their safety and therapeutic potential for healing fistulae associated with Crohn's disease. This study was carried out to evaluate the efficacy and safety of ASCs in patients with Crohn's fistulae. In this phase II study, forty-three patients were treated with ASCs. The amount of ASCs was proportioned to fistula size and fistula tract was filled with ASCs in combination with fibrin glue after intralesional injection of ASCs. Patients without complete closure of fistula at 8 weeks received a second injection of ASCs containing 1.5 times more cells than the first injection. Fistula healing at week 8 after final dose injection and its sustainability for 1-year were evaluated. Healing was defined as a complete closure of external opening without any sign of drainage and inflammation. A modified per-protocol analysis showed that complete fistula healing was observed in 27/33 patients (82%) by 8 weeks after ASC injection. Of 27 patients with fistula healing, 26 patients completed additional observation study for 1-year and 23 patients (88%) sustained complete closure. There were no adverse events related to ASC administration. ASC treatment for patients with Crohn's fistulae was well tolerated, with a favorable therapeutic outcome. Furthermore, complete closure was well sustained. These results strongly suggest that autologous ASC could be a novel treatment option for the Crohn's fistula with high-risk of recurrence. STEM CELLS2013;31:2575-2581 (c) 147.
URI
http://hdl.handle.net/YU.REPOSITORY/28587http://dx.doi.org/10.1002/stem.1357
ISSN
1066-5099
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의과대학 > 성형외과학교실 > Articles
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