Neurologic Complications and Outcomes of Pandemic (H1N1) 2009 in Korean Children

Title
Neurologic Complications and Outcomes of Pandemic (H1N1) 2009 in Korean Children
Author(s)
김세윤권순학[권순학]조민현[조민현]서혜은[서혜은]
Keywords
INFLUENZA-A H1N1; YOUNG-CHILDREN; INTENSIVE-CARE; RISK-FACTORS; ENCEPHALOPATHY; TEXAS
Issue Date
201204
Publisher
KOREAN ACAD MEDICAL SCIENCES
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE, v.27, no.4, pp.402 - 407
Abstract
Neurologic complications of children with influenza A H1N1 2009 pandemic, diagnosed in two consecutive influenza seasons were retrospectively reviewed to seek better outcomes in future outbreaks. Patient demographics, clinical manifestations and neurologic outcomes were reviewed. A total of 1,389 children were diagnosed with influenza A H1N1 by real-time reverse transcriptase-polymerase chain reaction. Of these, 23 (1.7%) patients had neurologic involvement. Their mean age was 5.9 +/- 3.6 yr (range, 6 months to 11 yr) and 16 (69.9%) were boys. None of the 23 patients had been vaccinated for influenza A H1N1 and seasonal influenzas. Twenty-two of the 23 patients presented with seizures. Clinical features included febrile convulsion (n = 19), afebrile convulsion (n = 1), aseptic meningitis (n = 1), encephalopathy (n = 1), and acute necrotizing encephalopathy (n = 1). They all were treated with Oseltamivir twice daily for 5 days immediately after nasal and throat swab testing. Twenty-one of the subjects recovered fully, but the youngest two infants experienced severe neurological sequelae. The results indicate that neurologic complications associated with influenza A H1N1 2009 pandemic were mostly mild, but rarely were serious. Prompt intervention leads to a better outcome and vaccination may prevent the disease, thus staving off serious neurological complications following influenza, especially in young infants.
URI
http://hdl.handle.net/YU.REPOSITORY/28573http://dx.doi.org/10.3346/jkms.2012.27.4.402
ISSN
1011-8934
Appears in Collections:
의과대학 > 소아청소년과학교실 > Articles
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