The effects of minimally invasive laser needle system on suppression of trabecular bone loss induced by skeletal unloading

Title
The effects of minimally invasive laser needle system on suppression of trabecular bone loss induced by skeletal unloading
Author(s)
정대원고창용[고창용]강희성[강희성]류연항[류연항]정병조[정병조]김현수신홍인[신홍인]임도형[임도형]김한성[김한성]
Keywords
INTENSITY ULTRASOUND STIMULATION; RAT CALVARIAL CELLS; SCIATIC-NERVE; 830-NM LASER; IRRADIATION; OSTEOBLASTS; MICROSTRUCTURE; MINERALIZATION; OSTEOCYTES; APOPTOSIS
Issue Date
201311
Publisher
SPRINGER LONDON LTD
Citation
LASERS IN MEDICAL SCIENCE, v.28, no.6, pp.1495 - 1502
Abstract
This study was aimed to evaluate the effects of low-level laser therapy (LLLT) in the treatment of trabecular bone loss induced by skeletal unloading. Twelve mice have taken denervation operation. At 2 weeks after denervation, LLLT (wavelength, 660 nm; energy density, 3 J/cm(2)) was applied to the right tibiae of six mice (LASER) for 5 days/week over 2 weeks by using a minimally invasive laser needle system (MILNS) which consists of a 100 mu m optical fiber in a fine needle (diameter, 130 mu m). Structural parameters and histograms of bone mineralization density distribution (BMDD) were obtained before LLLT and at 2 weeks after LLLT. In addition, osteocyte, osteoblast, and osteoclast populations were counted. Two weeks after LLLT, bone volume fraction, trabeculae number, and trabeculae thickness were significantly increased and trabecular separations, trabecular bone pattern factor, and structure model index were significantly decreased in LASER than SHAM (p < 0.05). BMDD in LASER was maintained while that in SHAM was shifted to lower mineralization. Osteocyte and osteoblast populations were significantly increased but osteoclast population was significantly decreased in LASER when compared with those in SHAM (p < 0.05). The results indicate that LLLT with the MILNS may enhance bone quality and bone homeostasis associated with enhancement of bone formation and suppression of bone resorption.
URI
http://hdl.handle.net/YU.REPOSITORY/28519http://dx.doi.org/10.1007/s10103-013-1265-x
ISSN
0268-8921
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의과대학 > 미생물학교실 > Articles
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