A novel synthesis of diverse 2-amino-5-hydroxy-4H-chromene derivatives with a spirooxindole nucleus by Ca(OH)(2)-mediated three-component reactions of substituted resorcinols with isatins and malononitrile

Title
A novel synthesis of diverse 2-amino-5-hydroxy-4H-chromene derivatives with a spirooxindole nucleus by Ca(OH)(2)-mediated three-component reactions of substituted resorcinols with isatins and malononitrile
Author(s)
이용록박지향김성홍[김성홍]
Keywords
THROUGHPUT SCREENING ASSAY; CATALYTIC ASYMMETRIC-SYNTHESIS; ONE-POT SYNTHESIS; INTRAMOLECULAR HECK REACTIONS; MAMMALIAN-CELL CYCLE; AQUEOUS-MEDIA; HETEROCYCLIC SYNTHESIS; ASPERGILLUS-FUMIGATUS; EFFICIENT SYNTHESIS; DISCOVERY
Issue Date
201311
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
TETRAHEDRON, v.69, no.46, pp.9682 - 9689
Abstract
An efficient and facile one-pot synthesis is described for the preparation of novel 2-amino-5-hydroxy-4H-chromene derivatives with a spirooxindole nucleus using Ca(OH)(2)-mediated three-component reactions of substituted resorcinols with isatins and malononitrile. This simple method provided a variety of biologically interesting diverse 2-amino-5-hydroxy-4H-chromene derivatives in moderate yields under mild reaction conditions. (c) 2013 Elsevier Ltd. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/28502http://dx.doi.org/10.1016/j.tet2013.09.021
ISSN
0040-4020
Appears in Collections:
공과대학 > 화학공학부 > Articles
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