Pharmacokinetics of hederacoside C, an active ingredient in AG NPP709, in rats

Title
Pharmacokinetics of hederacoside C, an active ingredient in AG NPP709, in rats
Author(s)
최혜덕KIM JM[KIM JM]YOON JN[YOON JN]JUNG JW[JUNG JW]SHIN YJ[SHIN YJ]HAN CK[HAN CK]LEE HS[LEE HS]강희은[강희은]
Keywords
EQUILIBRIUM DIALYSIS; PROTEIN-BINDING; PLASMA; HELIX; METABOLISM; SAPONINS
Issue Date
201311
Publisher
INFORMA HEALTHCARE
Citation
XENOBIOTICA, v.43, no.11, pp.985 - 992
Abstract
1. Hederacoside C (HDC) is one of the active ingredients in Hedera helix leaf extract (Ivy Ex.) and AG NPP709, a new botanical drug to treat acute respiratory infection and chronic inflammatory bronchitis. However, information regarding its pharmacokinetic properties remains limited. 2. Here, we report the pharmacokinetics of HDC in rats after intravenous administration of HDC (3, 12.5, and 25 mg/kg) and after oral administration of HDC, Ivy Ex., and AG NPP709 (equivalent to 12.5, 25, and 50 mg/kg HDC). 3. Linear pharmacokinetics of HDC were identified upon its intravenous administration at doses of 3-25 mg/kg. Intravenous administration of HDC results in relatively slow clearance (1.46-2.08 mL/min/kg) and a small volume of distribution at steady state (138-222 mL/kg), while oral administration results in a low absolute oral bioavailability (F) of 0.118-0.250%. The extremely low F of HDC may be due to poor absorption of HDC from the gastrointestinal (GI) tract and/or its decomposition therein. 4. The oral pharmacokinetics of HDC did not differ significantly among pure HDC, Ivy Ex., and AG NPP709.
URI
http://hdl.handle.net/YU.REPOSITORY/28484http://dx.doi.org/10.3109/00498254.2013.788231
ISSN
0049-8254
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약학대학 > 약학부 > Articles
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