A Preclinical Murine Model for the Detection of Circulating Human Tumor Cells

Title
A Preclinical Murine Model for the Detection of Circulating Human Tumor Cells
Author(s)
정지헌안지영[안지영]민혜영[민혜영]변영로[변영로]이호영[이호영]
Keywords
BREAST-CANCER; GASTRIC-CANCER; NUDE-MICE; SUPPRESSION; METASTASIS; ENRICHMENT; CARCINOMA; MARKER
Issue Date
201311
Publisher
INT INST ANTICANCER RESEARCH
Citation
ANTICANCER RESEARCH, v.33, no.11, pp.4751 - 4756
Abstract
Background/Aim: Circulating tumor cells (CTCs), cancer cells that disseminate from primary tumors and enter the bloodstream in the course of metastasis, may serve as an important indicator of metastatic disease and poor prognosis in patients with cancer. The aim of this study was to establish a preclinical animal model for detecting and studying human CTCs. Materials and Methods: We performed a renal subcapsular implantation of human cancer cells in immunodeficient mice and recorded primary tumor growth, CTCs, and metastatic tumor development. Results: Immunofluorescence, or immunohistochemical staining and whole-body imaging analysis revealed that the implanted cells developed primary renal tumors, CTCs were detected, and successfully established metastatic tumors in several organs, including the lung, colon, and lymph nodes, depending on the implanted cells. Conclusion: This model may be useful for detecting and characterizing CTCs and for investigating the mechanisms underlying the course of tumor metastasis.
URI
http://hdl.handle.net/YU.REPOSITORY/28482
ISSN
0250-7005
Appears in Collections:
약학대학 > 약학부 > Articles
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