Effects of Silicone-Based Gels Containing Allantoin, Dexpanthenol and Heparin on Hypertrophic Scarring in the Rabbit Ear Model

Title
Effects of Silicone-Based Gels Containing Allantoin, Dexpanthenol and Heparin on Hypertrophic Scarring in the Rabbit Ear Model
Author(s)
김종오용철순김건국구세광[구세광]이동원마라시니[마라시니]로샨[로샨]손미원[손미원]전준호[전준호]장선우[장선우]진성규[진성규]강민경[강민경]최한곤[최한곤]
Keywords
SCARS; EPIDERMIS
Issue Date
201205
Publisher
WILEY-BLACKWELL
Citation
DRUG DEVELOPMENT RESEARCH, v.73, no.3, pp.146 - 153
Abstract
Strategy, Management and Health Policy Enabling Technology, Genomics, Proteomics Preclinical Research Preclinical Development Toxicology, Formulation Drug Delivery, Pharmacokinetics Clinical Development Phases I-III Regulatory, Quality, Manufacturing Postmarketing Phase IV Silicone-based formulations are extensively used for the management of hypertrophic scars. Although the exact mechanism of action is still unknown, it has been postulated that some occlusion and hydration of the stratum corneum with subsequent cytokine-mediated signaling from keratinocytes to dermal fibroblasts is involved in its antiscarring effects. In this study, the effectiveness of silicone-based gels containing allantoin, dexpanthenol, and heparin was evaluated for improving the healing of hypertrophic scars. It was found that silicone-based gels showed remarkable improvements in hypertrophic scar healing and low amounts of skin pigmentation in the rabbit ear model compared with the nontreated control or base alone. Furthermore, the histopathological and histomorphometrical profiles of three different formulations containing 1%, 5%, and 20% silicone contents exhibited marked or significant decreases in the scar elevation index, anterior skin and epithelial thicknesses, inflammatory cells, vessels, collagen disorganization, and fibroblasts compared with nontreated control hypertrophic scars. Therefore, these results indicate that silicone-based gels containing heparin, allantoin, and dexpanthenol could be promising formulations for the healing of hypertrophic scars.
URI
http://hdl.handle.net/YU.REPOSITORY/28400http://dx.doi.org/10.1002/ddr.21004
ISSN
0272-4391
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약학대학 > 약학부 > Articles
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