New topoisomerases inhibitors: Synthesis of rutaecarpine derivatives and their inhibitory activity against topoisomerases

Title
New topoisomerases inhibitors: Synthesis of rutaecarpine derivatives and their inhibitory activity against topoisomerases
Author(s)
장영동김승일[김승일]이승호이응석이종순
Keywords
EVODIA-RUTAECARPA; ALKALOIDS; CONSTITUENTS; AGGREGATION; MECHANISM; ANALOGS
Issue Date
201205
Publisher
PHARMACEUTICAL SOC KOREA
Citation
ARCHIVES OF PHARMACAL RESEARCH, v.35, no.5, pp.785 - 789
Abstract
A series of rutaecarpine derivatives were prepared by employing previously reported methods and their inhibitory activities against topoisomerase I and II were evaluated. Among them, strongly cytotoxic 10-bromorutaecarpine and 3-chlororutaecarpine showed strong inhibitory activities against topo I and II.
URI
http://hdl.handle.net/YU.REPOSITORY/28395http://dx.doi.org/10.1007/s12272-012-0504-1
ISSN
0253-6269
Appears in Collections:
약학대학 > 약학부 > Articles
이과대학 > 화학생화학부 > Articles
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