Pharmacokinetics and correlation analysis of cilostazol in healthy Korean subjects

Title
Pharmacokinetics and correlation analysis of cilostazol in healthy Korean subjects
Author(s)
최혜덕LEE HJ[LEE HJ]LEE SH[LEE SH]KIM SH[KIM SH]최청암[최청암]장민정[장민정]신완균[신완균]
Keywords
GENETIC POLYMORPHISMS; SINGLE; METABOLITES; IMPAIRMENT; CYP2C19; CYP3A5
Issue Date
201205
Publisher
DUSTRI-VERLAG DR KARL FEISTLE
Citation
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, v.50, no.5, pp.345 - 348
Abstract
Background: Cilostazol is frequently used to treat and prevent thrombosis in Korean patients. Patients and methods: We performed the pharmacokinetic and correlation analysis of cilostazol in Korean healthy subjects. A total of male 78 volunteers was subjected to three separate bioequivalence studies in which 100 mg of cilostazol was administered. AUC, t(1/2), and C-max were 12,100 +/- 4,880 ngxh/ml, 11.1 +/- 4.4 hours, and 827 +/- 361 ng/ml, respectively. Results: ALT was positively correlated with age and C-max was positively correlated with AUC, but negatively correlated with body weight. Conclusion: We suggest that the unique pharmacokinetic parameters and interrelationship can help to understand the pharmacokinetics of cilostazol in Korean subjects.
URI
http://hdl.handle.net/YU.REPOSITORY/28347http://dx.doi.org/10.5414/CP201671
ISSN
0946-1965
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약학대학 > 약학부 > Articles
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