Geraniol induces cooperative interaction of apoptosis and autophagy to elicit cell death in PC-3 prostate cancer cells

Title
Geraniol induces cooperative interaction of apoptosis and autophagy to elicit cell death in PC-3 prostate cancer cells
Author(s)
박현호전주홍[전주홍]김수화[김수화]박은정[박은정]이채련[이채련]천정려[천정려]조남혁[조남혁]김인규[김인규]이상훈[이상훈]김태우[김태우]서인석[서인석]
Keywords
PTEN; GROWTH; THERAPY; RESISTANCE; BIOSYNTHESIS; INACTIVATION; SURVIVAL; FARNESOL; TARGET
Issue Date
201205
Publisher
SPANDIDOS PUBL LTD
Citation
INTERNATIONAL JOURNAL OF ONCOLOGY, v.40, no.5, pp.1683 - 1690
Abstract
Geraniol, an acyclic dietary monoterpene, suppresses prostate cancer growth and enhances docetaxel chemosensitivity in cultured cell or xenograft tumor models. However, the mechanisms of the geraniol action against prostate cancer are largely unknown. In this study, we investigated the cellular and molecular mechanisms of geraniol-induced cell death in PC-3 prostate cancer cells. Among the examined structurally and functionally similar monoterpenes, geraniol potently induced apoptosis and autophagy. Although independent processes, apoptosis and autophagy acted as cooperative partners to elicit geraniol-induced cell death in PC-3 cells. At a molecular level, geraniol inhibited Ala signaling and activated AMPK signaling, resulting in mTOR inhibition. Combined treatment of AKT inhibitor and AMPK activator markedly suppressed cell growth compared to either treatment alone. Our findings provide insight into future investigations that are aimed at elucidating the role of apoptosis and autophagy in prostate cancer therapy and at developing anticancer strategies co-targeting AKT and AMPK.
URI
http://hdl.handle.net/YU.REPOSITORY/28343http://dx.doi.org/10.3892/ijo.2011.1318
ISSN
1019-6439
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이과대학 > 화학생화학부 > Articles
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