Interkingdom signaling by structurally related cyanobacterial and algal secondary metabolites

Title
Interkingdom signaling by structurally related cyanobacterial and algal secondary metabolites
Author(s)
최혁재Lena Gerwick[Lena Gerwick]Paul Boudreau[Paul Boudreau]Samantha J. Mascuch[Samantha J. Mascuch]Francisco A. Villa[Francisco A. Villa]Marcy J. Balunas, [Marcy J. Balunas, ]Karla L. Malloy[Karla L. Malloy]Margaret E. Teasdale[Margaret E. Teasdale]David C. Rowley [David C. Rowley ]William H. Gerwick[William H. Gerwick]
Keywords
LYNGBYA-MAJUSCULA; MARINE; TRANSCRIPTION; MALYNGAMIDE; LAURENCIONE; MOLECULE; LACTONE
Issue Date
201205
Publisher
SPRINGER
Citation
PHYTOCHEMISTRY REVIEWS, v.12, no.3, pp.459 - 465
Abstract
Several groups of structurally-related compounds, comprised of either five or six-membered ring structures with attached lipophilic carbon chains and in some cases possessing halogen atoms, have been isolated from various marine algae and filamentous cyanobacteria. The related compounds considered in the present work include the coibacins, laurenciones, honaucins, malyngamides and the tumonoic acids. Members of all of these compound families were assayed and found to inhibit the production of nitric oxide in lipopolysaccharides-stimulated macrophages, indicating their anti-inflammatory potential. In addition, several of these same marine natural products were found to inhibit quorum sensing mediated phenotypes in Vibrio harveyi BB120 and/or Escherichia coli JB525. The mechanism and evolutionary significance for inhibition of these cellular processes in prokaryotic and eukaryotic systems are speculated on and discussed.
URI
http://hdl.handle.net/YU.REPOSITORY/28316http://dx.doi.org/10.1007/s11101-012-9237-5
ISSN
1568-7767
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약학대학 > 약학부 > Articles
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