Functionalizing cellulose scaffold prepared by ionic liquid with bovine serum albumin for biomedical application

Title
Functionalizing cellulose scaffold prepared by ionic liquid with bovine serum albumin for biomedical application
Author(s)
한성수신은주최순모이양헌[이양헌]조선미딥티싱
Keywords
DISSOLUTION; CHLORIDE; SOLVENT
Issue Date
201312
Publisher
KOREAN FIBER SOC
Citation
FIBERS AND POLYMERS, v.14, no.12, pp.1965 - 1969
Abstract
The present study reports the preparation of a cellulose scaffold for tissue engineering directly from cellulose fiber using ionic liquid (IL) by the NaCl leaching method with bovine serum albumin (BSA), which is well known protein utilized for biomedical applications like degradation of polymer, cell attachment and proliferation on scaffold. The 1-n-allyl-3-methylimidazolium chloride (AmimCl) IL was used as a solvent for cellulose. The morphology of the scaffold was studied by scanning electron microscopy (SEM) and the images showed that the pore sizes of the scaffolds were about 200 A mu m. In addition, the water uptake (WU) and degree of degradation of the cellulose scaffold were measured. Meanwhile, the biocompatibility and bioactivity of the scaffold were determined via 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenytetrazolium bromide (MTT) assay and the Live/Dead viability test. The various results demonstrated the ability of the Mesenchymal stem cells (MSC) to attach to the surface of the scaffolds amplified as percentage of BSA increased in cellulose scaffold.
URI
http://hdl.handle.net/YU.REPOSITORY/28299http://dx.doi.org/10.1007/s12221-013-1965-7
ISSN
1229-9197
Appears in Collections:
공과대학 > 화학공학부 > Articles
공과대학 > 융합섬유공학과 > Articles
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