Autocrine and paracrine modulation of microRNA-155 expression by globular adiponectin in RAW 264.7 macrophages: Involvement of MAPK/NF-kappa B pathway

Title
Autocrine and paracrine modulation of microRNA-155 expression by globular adiponectin in RAW 264.7 macrophages: Involvement of MAPK/NF-kappa B pathway
Author(s)
박필훈수베디아미트
Keywords
TNF-ALPHA; ACTIVATION; INFLAMMATION; APOPTOSIS; MIR-155; CELLS; P38; ERK
Issue Date
201312
Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Citation
CYTOKINE, v.64, no.3, pp.638 - 641
Abstract
Adiponectin, a hormone produced from adipose tissue, regulates various biological responses, including inflammation and many metabolic processes. MicroRNAs control expression of diverse target genes and various physiological responses. Many of these responses are commonly regulated by adiponectin. However, effects of adiponectin on microRNAs regulation are largely unknown. Herein we demonstrated that globular adiponectin induces increase in miR-155 expression, which plays an important role in inflammatory response, in RAW 264.7 macrophages. We further showed that this effect was modulated by and MANK/NF-kappa B dependent mechanisms. These results suggest that miR-155 would be a novel promising target mediating adiponectin-induced various biological responses. (C) 2013 Elsevier Ltd. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/28255http://dx.doi.org/10.1016/j.cyto.2013.09.011
ISSN
1043-4666
Appears in Collections:
약학대학 > 약학부 > Articles
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