Anti-allergic Inflammatory Effects of Cyanogenic and Phenolic Glycosides from the Seed of Prunus persica

Title
Anti-allergic Inflammatory Effects of Cyanogenic and Phenolic Glycosides from the Seed of Prunus persica
Author(s)
이승호김금진최현규김지향김상현[김상현]김정아[김정아]
Keywords
CONSTITUENTS; ANTIOXIDANT; LIGNANS
Issue Date
201312
Publisher
NATURAL PRODUCTS INC
Citation
NATURAL PRODUCT COMMUNICATIONS, v.8, no.12, pp.1739 - 1740
Abstract
A methanol extract of the seed of Prunus persica (Rosaceae) was found to inhibit histamine release in human mast cells. Activity-guided fractionation of the methanol extract yielded three cyanogenic glycosides (1-3) and other phenolic compounds (4-8). To evaluate their anti-allergic and anti-inflammatory activities, the isolates (1-8) were tested for their inhibitory effects on histamine release and on the gene expressions of tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 in human mast cells. Of these, phenolic glycosides 7 and 8 suppressed histamine release and inhibited the pro-inflammatory cytokines TNF-alpha and IL-6. These results suggest that isolates from P. persica are among the anti-allergic inflammatory principles in this medicinal plant.
URI
http://hdl.handle.net/YU.REPOSITORY/28249
ISSN
1934-578X
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약학대학 > 약학부 > Articles
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