Protective Effects of Vitamin E on Chemotherapy-Induced Peripheral Neuropathy: A Meta-Analysis of Randomized Controlled Trials

Title
Protective Effects of Vitamin E on Chemotherapy-Induced Peripheral Neuropathy: A Meta-Analysis of Randomized Controlled Trials
Author(s)
최혜덕엄시내[엄시내]장민정[장민정]CHOI HC[CHOI HC]KO YJ[KO YJ]AHN JS[AHN JS]신완균[신완균]이주연[이주연]
Keywords
LEUKEMIA INHIBITORY FACTOR; PHASE-II TRIAL; E SUPPLEMENTATION; CISPLATIN NEUROPATHY; FACTOR RHULIF; PREVENTION; CANCER; THERAPY; ANTIOXIDANTS; PACLITAXEL
Issue Date
201312
Publisher
VERLAG HANS HUBER
Citation
INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH, v.83, no.2, pp.101 - 111
Abstract
Purpose: This study aimed to investigate the neuroprotective effects of vitamin E for preventing chemotherapy-induced peripheral neuropathy (CIPN). Methods: A comprehensive search from 1973 through July 2011 identified randomized controlled trials (RCTs) that reported the preventive effects of vitamin E on CIPN. The relative risk (RR) of CIPN with vitamin E supplementation, compared with placebo, was assessed with the Bayesian random effect model and expressed as RR with a 95 % credible-interval (CrI). Bayesian outcome probabilities were calculated as the probability (P) of RR <1. Results: Five RCTs, involving 319 patients, were identified. Upon pooling these RCTs, vitamin E supplementation (300-600 mg/day) had a significant effect on CIPN prevention (RR 0.43; 95 % CrI 0.10-1.00, P = 97.5 %). Subgroup analysis by chemotherapeutic agent type was only available for cisplatin and showed that vitamin E supplementation significantly reduced the incidence of CIPN (RR 0.26; 95% CrI 0.06-0.89, P = 98.1 %). Furthermore, there were no adverse effects caused by vitamin E supplementation in any of the RCTs. Conclusion: Available data included in this meta-analysis show that vitamin E supplementation might significantly prevent CIPN. Currently, however, the data are insufficient to confidently conclude the true value. Large-scale, rigorously designed RCTs are needed to confirm the role of vitamin E supplementation in CIPN prevention.
URI
http://hdl.handle.net/YU.REPOSITORY/28214http://dx.doi.org/10.1024/0300-9831/000149
ISSN
0300-9831
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약학대학 > 약학부 > Articles
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