Synthesis, Characterization, and Anti-Amoebic Activity of N-(Pyrimidin-2yl) benzenesulfonamide Derivatives

Title
Synthesis, Characterization, and Anti-Amoebic Activity of N-(Pyrimidin-2yl) benzenesulfonamide Derivatives
Author(s)
최인호압둘루프바트Mohammad Arshad[Mohammad Arshad]이은주포커렐스미리티Fareeda Athar[Fareeda Athar]
Keywords
CARBONIC-ANHYDRASE-II; REDUCED METRONIDAZOLE; DNA BASES; SULFAMETHOXAZOLE; CYTOTOXICITY; INHIBITORS; AFFINITY; BINDING; AGENTS; ACID
Issue Date
201312
Publisher
WILEY-V C H VERLAG GMBH
Citation
CHEMISTRY & BIODIVERSITY, v.10, no.12, pp.2267 - 2277
Abstract
A new series of N-(pyrimidin-2-yl)benzenesulfonamide derivatives, 3a-3i and 4a-4i, was synthesized from pyrimidin-2-amines, 2a-2i, with the aim to explore their effects on in vitro growth of Entamoeba histolytica. The chemical structures of the compounds were elucidated by elemental analysis, FT-IR, H-1- and C-13-NMR, and ESI mass-spectral data. In vitro anti-amoebic activity was evaluated against HM1:IMSS strain of Entamoeba histolytica. The IC50 values were calculated by using the double dilution method. The results were compared with the IC50 value of the standard drug metronidazole'. The selected compounds were tested for their cytotoxic activities by cell-viability assay using H9C2 cardiac myoblasts cell line, and the results indicated that all the compounds displayed remarkable >80% viabilities to a concentration of 100 mu g/ml.
URI
http://hdl.handle.net/YU.REPOSITORY/28204http://dx.doi.org/10.1002/cbdv.201300009
ISSN
1612-1872
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생명공학부 > 생명공학부 > Articles
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