Neural injury of uncinate fasciculus in patients with diffuse axonal injury

Title
Neural injury of uncinate fasciculus in patients with diffuse axonal injury
Author(s)
장성호서정표김오룡김성호장민철김민수손수민
Keywords
TRAUMATIC BRAIN-INJURY; CLOSED-HEAD TRAUMA; LONGITUDINAL CHANGES; TENSOR TRACTOGRAPHY; IMPAIRMENT; CLINICIAN; TRACKING; LESIONS; MR
Issue Date
201206
Publisher
IOS PRESS
Citation
NEUROREHABILITATION, v.30, no.4, pp.323 - 328
Abstract
The recent development of diffusion tensor imaging (DTI) allows visualization and estimation of the uncinate fascicul us (UF). We investigated injuries of the UF in patients with diffuse axonal injury (DAI) who showed no specific lesions except for DAI lesions on conventional brain MRI. Twenty-one chronic patients with DAI, and 21 age- and sex-matched normal control subjects were recruited for this study. Diffusion tensor images were acquired using a sensitivity-encoding head coil at 1.5 T and the UF was reconstructed using DTI-Studio software. Fractional anisotropy (FA), apparent diffusion coefficient (ADC) value, and fiber number of the UF were measured. In the DAI group, the FA values and fiber numbers were significantly decreased compared to those of the control group (P < 0.05). The FA value and fiber number decreased 8.4% and 26.5% in the DAI group compared to those of the control group. By contrast, the ADC value did not show any difference between the DAI and control groups (P > 0.05). Changes in the DTI parameters of the DAI group appeared to indicate neural injury of the UF. We believe that DTI can be a useful evaluation tool for detecting hidden neural injuries of UF in patients with DAI.
URI
http://hdl.handle.net/YU.REPOSITORY/28169http://dx.doi.org/10.3233/NRE-2012-0762
ISSN
1053-8135
Appears in Collections:
의과대학 > 재활의학교실 > Articles
의과대학 > 신경외과학교실 > Articles
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