Pharmacokinetics of Clindamycin in the Plasma and Dialysate after Intraperitoneal Administration of Clindamycin Phosphoester to Patients on Continuous Ambulatory Peritoneal Dialysis: An Open-Label, Prospective, Single-Dose, Two-Institution Study

Title
Pharmacokinetics of Clindamycin in the Plasma and Dialysate after Intraperitoneal Administration of Clindamycin Phosphoester to Patients on Continuous Ambulatory Peritoneal Dialysis: An Open-Label, Prospective, Single-Dose, Two-Institution Study
Author(s)
최혜덕장민정[장민정]남궁형욱[남궁형욱]Song YR[Song YR]Kim SG[Kim SG]오정미[오정미]신완균[신완균]
Keywords
INFECTIONS RECOMMENDATIONS; CEFAZOLIN; PHOSPHATE; UPDATE; BIOAVAILABILITY; MORTALITY; KINETICS; CAPD
Issue Date
201206
Publisher
WILEY-BLACKWELL
Citation
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, v.110, no.6, pp.504 - 509
Abstract
We evaluated the pharmacokinetics of clindamycin and the dose of clindamycin phosphate necessary to treat peritonitis after intraperitoneal administration of clindamycin phosphate to patients on continuous ambulatory peritoneal dialysis (CAPD). This was an open-label, prospective, single-dose study conducted at the two levels of institutional clinical care in South Korea. Twelve patients (six men and six women; all older than 25 years), mean CAPD duration of 38.2 months with various origins without peritonitis, received 600 mg clindamycin phosphate mixed with only the first 2-L dialysate (1.5% dextrose). The 1.5%, 1.5%, 2.5% and 1.5% dextrose dialysates were serially exchanged every 6 hr. If patients were non-anuric, 24-hr urine samples were also collected. Clindamycin phosphate was incompletely activated to clindamycin in the dialysate. The clindamycin concentration in the dialysate was greater than the effective concentration (5 mu g/mL) at 6.87 mu g/mL up to 6 hr. So, 600 mg clindamycin phosphate per every 6 hr dialysate is effective for treatment of peritonitis. It has been reported that the clindamycin concentrations in the dialysate may be higher in CAPD patients with peritonitis. Thus, we can expect that intraperitoneal administration of <600 mg clindamycin phosphate per every 6 hr dialysate could be maintained over 5 mu g/mL in patients with peritonitis. The transfer of clindamycin was unidirectional from the dialysate to the plasma.
URI
http://hdl.handle.net/YU.REPOSITORY/28128http://dx.doi.org/10.1111/j.1742-7843.2011.00842.x
ISSN
1742-7835
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약학대학 > 약학부 > Articles
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