Polypeptide nanogels with hydrophobic moieties in the cross-linked ionic cores: synthesis, characterization and implications for anticancer drug delivery

Title
Polypeptide nanogels with hydrophobic moieties in the cross-linked ionic cores: synthesis, characterization and implications for anticancer drug delivery
Author(s)
김종오Hardeep S. Oberoi[Hardeep S. Oberoi]Swapnil Desale[Swapnil Desale]Alexander V. Kabanov[Alexander V. Kabanov]Tatiana K. Bronich[Tatiana K. Bronich]
Keywords
TRIBLOCK COPOLYMER MICELLES; SOLVATION DYNAMICS; BLOCK-COPOLYMER; COUMARIN-153; VESICLES; CANCER; ACID); SURFACTANTS; PROTEASES; PLATFORM
Issue Date
201312
Publisher
INFORMA HEALTHCARE
Citation
JOURNAL OF DRUG TARGETING, v.21, no.10, pp.981 - 993
Abstract
Polymer nanogels have gained considerable attention as a potential platform for drug delivery applications. Here we describe the design and synthesis of novel polypeptide-based nanogels with hydrophobic moieties in the cross-linked ionic cores. Diblock copolymer, poly(ethylene glycol)-b-poly(L-glutamic acid), hydrophobically modified with L-phenylalanine methyl ester moieties was used for controlled template synthesis of nanogels with small size (ca. 70nm in diameter) and narrow particle size distribution. Steady-state and time-resolved fluorescence studies using coumarin C153 indicated the existence of hydrophobic domains in the ionic cores of the nanogels. Stable doxorubicin-loaded nanogels were prepared at high drug capacity (30 w/w%). We show that nanogels are enzymatically-degradable leading to accelerated drug release under simulated lysosomal acidic pH. Furthermore, we demonstrate that the nanogel-based formulation of doxorubicin is well tolerated and exhibit an improved antitumor activity compared to a free doxorubicin in an ovarian tumor xenograft mouse model. Our results signify the point to a potential of these biodegradable nanogels as attractive carriers for delivery of chemotherapeutics.
URI
http://hdl.handle.net/YU.REPOSITORY/28114http://dx.doi.org/10.3109/1061186X.2013.831421
ISSN
1061-186X
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약학대학 > 약학부 > Articles
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