Cytomegalovirus Infection in Patients with New Onset Ulcerative Colitis: A Prospective Study

Title
Cytomegalovirus Infection in Patients with New Onset Ulcerative Colitis: A Prospective Study
Author(s)
장병익김유선[김유선]김영호[김영호]김주성[김주성]천재희[천재희]예병덕[예병덕]정성애[정성애]박영숙[박영숙]최창환[최창환]한동수[한동수]양석균[양석균]김원호[김원호]
Keywords
INFLAMMATORY-BOWEL-DISEASE; CLINICAL-SIGNIFICANCE; CMV ANTIGENEMIA; PREVALENCE; TRANSPLANTATION; DIAGNOSIS
Issue Date
201206
Publisher
H G E UPDATE MEDICAL PUBLISHING S A
Citation
HEPATO-GASTROENTEROLOGY, v.59, no.116, pp.1098 - 1101
Abstract
Background/Aims: Immunosuppressive therapy in ulcerative colitis (UC) may induce cytomegalovirus (CMV) infection or reactivation in the colonic mucosa and in turn exacerbate UC. However, it is unclear whether colonic inflammation itself affects CMV infection in UC. This prospective study evaluated the prevalence and clinical outcome of CMV infection in patients with new onset UC who have not been exposed to UC medication. Methodology: A prospective, multi-center study was conducted in 65 patients with new onset UC. The presence of CMV was evaluated by a serology test and a histopathological examination including immunohistochemical staining. The assessment of clinical outcome was performed based on CMV positivity. Results: Evidence of CMV infection was found in three (4.5%) patients with UC. Two patients with moderate disease activity improved with 5-aminosalicylate or steroid treatment. One patient with severe active colitis, however, required antiviral therapy. Conclusions: CMV infection is rare in new onset UC, which suggests that use of immunosuppressive medications is an important risk factor for CMV infection in UC. However, CMV evaluation is necessary for severe active UC, even with new onset of the disease.
URI
http://hdl.handle.net/YU.REPOSITORY/28113http://dx.doi.org/10.5754/hge10217
ISSN
0172-6390
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의과대학 > 내과학교실 > Articles
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