Design, synthesis, and antitumor evaluation of 2,4,6-triaryl pyridines containing chlorophenyl and phenolic moiety

Title
Design, synthesis, and antitumor evaluation of 2,4,6-triaryl pyridines containing chlorophenyl and phenolic moiety
Author(s)
Pritam Thapa[Pritam Thapa]Radha Karki[Radha Karki]윤민호[윤민호]Tara Man Kadayat[Tara Man Kadayat]이은영[이은영]권한별[권한별]나영화[나영화]조원제[조원제]김남두[김남두]정병선권영주[권영주]이응석
Keywords
II INHIBITORY-ACTIVITY; TOPOISOMERASE-I; DNA TOPOISOMERASES; CYTOTOXICITY; DERIVATIVES
Issue Date
201206
Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Citation
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.52, pp.123 - 136
Abstract
We have designed and synthesized a series of 2,4,6-triaryl pyridine derivatives containing chlorophenyl and phenolic moeity at 2- and 4- position of the central pyridine, respectively, resulting in a total of 42 compounds. They were evaluated for topoisomerase I and 11 inhibitory activities as well as cytotoxicities against several human cancer cell lines. Most compounds showed better topoisomerase II inhibitory activity compared to topoisomerase 1 inhibitory activity. Compounds 19, 20, 26-28, and 47-50 especially showed stronger topo II inhibitory activity than etoposide. (C) 2012 Elsevier Masson SAS. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/28100http://dx.doi.org/10.1016/j.ejmech.2012.03.010
ISSN
0223-5234
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약학대학 > 약학부 > Articles
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