Inhibitory effects of sugiol, a biologically active abietane type diterpenoid from Metasequoia glyptostroboides
- Inhibitory effects of sugiol, a biologically active abietane type diterpenoid from Metasequoia glyptostroboides
- 비벡바지파이; 백광현; 강선철[강선철]
- ANTIFUNGAL ACTIVITY; CANDIDA-ALBICANS; DRUG-RESISTANCE; EPIDEMIOLOGY; ANTIBACTERIAL
- Issue Date
- ARS DOCENDI
- ROMANIAN BIOTECHNOLOGICAL LETTERS, v.17, no.3, pp.7287 - 7294
- This study was aimed to evaluate the antifungal effects of an abietane type diterpenoid, sugiol isolated from Metasequoia glyptostroboides against different clinical isolates of Candida species. The sugiol (100 mu g/disc) evoked potential antifungal effect as a diameter of zones of inhibition against Candida albicans KBN06P00076, C. albicans KBN06P00074, C. glabrata KBN06P00066, C. glabrata KBN06P00068, C. tropicalis KBN06P00682, C. tropicalis KBN06P00058, C. parapsilosis KBN06P00060, C. parapsilosis KBN06P00055 and C. guilliermondii KBN06P00492, C. guilliermondii KBN06P00867, which was ranged from 8 to 13 mm. The minimum inhibitory (MIC) and minimum fungicidal (MFC) concentrations values of sugiol against the employed fungal pathogens were found in the range of 125 to 1000 and 125 to 2000 mu g/ml, respectively. Also the sugiol exerted a remarkable antifungal effect on the viable counts of the tested fungal pathogens. These results demonstrate potent therapeutic efficacy of a diterpenoid compound sugiol from M. glyptostroboides.
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