Lipid emulsion as a drug delivery system for breviscapine: Formulation development and optimization

Title
Lipid emulsion as a drug delivery system for breviscapine: Formulation development and optimization
Author(s)
김종오Lijun Wei[Lijun Wei]Gao Li[Gao Li]로샨[로샨]엄의동Qizhe Quan[Qizhe Quan]
Keywords
CEREBRAL ISCHEMIA/REPERFUSION; SCUTELLARIN; BIODISTRIBUTION; NANOPARTICLES
Issue Date
201206
Publisher
PHARMACEUTICAL SOC KOREA
Citation
ARCHIVES OF PHARMACAL RESEARCH, v.35, no.6, pp.1037 - 1043
Abstract
In this study, we developed an optimized formulation of a breviscapine lipid emulsion (BLE) and evaluated the physicochemical properties and in vivo pharmacokinetics of BLE in rats. For the preparation of the lipid emulsion, soybean oil and oleic acid were used as the oil phase, lecithin and poloxamer 188 as surfactants and glycerol as co-surfactant. An optimized formulation consisting of soybean oil (10.0%), oleic acid (0.9%), lecithin (1.5%), poloxamer 188 (0.4%), and glycerol (2.25%) was selected. The results showed that the average particle size, polydispersity index, and zeta potential of the optimized formulation were 183.5 +/- 5.5 nm, 0.098 +/- 0.046, and -35.0 +/- 2.5 mV, respectively. The BLE was stable for at least three month at room temperature. After a single intravenous dose of 4 mg/kg to rats, the AUC of scutellarin from the lipid emulsion was about 1.5-fold higher than that of the commercial product (breviscapine injection). In conclusion, the optimized formulation of BLE showed positive results over the commercial product in terms of the physicochemical properties and pharmacokinetics of BLE in rats.
URI
http://hdl.handle.net/YU.REPOSITORY/28080http://dx.doi.org/10.1007/s12272-012-0611-z
ISSN
0253-6269
Appears in Collections:
약학대학 > 약학부 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE