Fabrication of Pamidronic Acid-Immobilized TiO2/Hydroxyapatite Composite Nanofiber Mats for Biomedical Applications

Title
Fabrication of Pamidronic Acid-Immobilized TiO2/Hydroxyapatite Composite Nanofiber Mats for Biomedical Applications
Author(s)
김석영신용석[신용석]Jyoti S. Borah[Jyoti S. Borah]Adnan Haider[Adnan Haider]Man-Woo Huh[Man-Woo Huh]Inn-Kyu Kang[Inn-Kyu Kang]
Keywords
IN-VITRO; TITANIUM IMPLANTS; HYDROXYAPATITE; BISPHOSPHONATES; BONE; COATINGS; SURFACE; PROLIFERATION; BIOCERAMICS; MECHANISMS
Issue Date
201312
Publisher
HINDAWI PUBLISHING CORPORATION
Citation
JOURNAL OF NANOMATERIALS
Abstract
TiO2/hydroxyapatite (TiO2/HA) composite nanofiber mats were fabricated using an electrospinning technique. Subsequently, pamidronic acid (PDA) was immobilized on the surface of the TiO2/HA nanofiber mat to improve osseointegration. X-ray photoelectron microscopy and scanning electron microscopy (SEM) were used to characterize the structure and morphology of the PDA-immobilized TiO2/HA composite nanofiber mat (TiO2/HA-P). The potential of TiO2/HA-P as a bone scaffold was assessed by examining the cell adhesion and proliferation of osteoblasts and osteoclasts. The adhesion and proliferation of osteoblasts on the TiO2/HA-P composite nanofiber mat were slightly higher than those on the TiO2/HA composite nanofiber mat, whereas the viability of osteoclasts on the TiO2/HA-P nanofiber mat was significantly suppressed. These results suggest that the TiO2/HA-P nanofiber mat has the potential for use as a therapeutic bone implant.
URI
http://hdl.handle.net/YU.REPOSITORY/28012http://dx.doi.org/10.1155/2013/404210
ISSN
1687-4110
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공과대학 > 신소재공학부 > Articles
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