Diabetogenic effect of statins: A double-edged sword?

Title
Diabetogenic effect of statins: A double-edged sword?
Author(s)
윤지성이형우
Keywords
atorvastatin; hydroxymethylglutaryl coenzyme A reductase inhibitor; placebo; pravastatin; rosuvastatin; simvastatin; clinical trial (topic); diabetes mellitus; diabetogenesis; disease association; dose response; drug dose comparison; drug safety; human; hyperlipidemia; nonhuman; pathophysiology; patient identification; review; risk assessment; risk benefit analysis; treatment outcome
Issue Date
201312
Citation
Diabetes and Metabolism Journal, v.37, no.6, pp.415 - 422
Abstract
Statins are widely prescribed cholesterol-lowering agents, which have been demonstrated to significantly reduce cardiovascular morbidity and mortality. However, recent trials have reported that statins cause worsening of hyperglycemia and increase the risk of new-onset diabetes. The association between the diabetogenic effect of statins with intensive dose and accompanying major risk factors for diabetes has been demonstrated. However, statins do not appear to have a class effect on insulin sensitivity in non-diabetic patients. Numerous mechanisms have been suggested to explain how statins cause ��-cell insulin secretory dysfunction and peripheral insulin resistance leading to incident diabetes. According to findings from an aggregate of large clinical trials, the benefits of statin treatment appear to outweigh the risk of new-onset diabetes. Therefore, it would be inappropriate to discontinue the use of statins for prevention of cardiovascular events because of its potential risk for development of incident diabetes. This review addresses the currently available evidence related to statin use and new-onset diabetes from a clinical perspective. ? 2013 Korean Diabetes Association.
URI
http://hdl.handle.net/YU.REPOSITORY/28006http://dx.doi.org/10.4093/dmj.2013.37.6.415
ISSN
2233-6079
Appears in Collections:
의과대학 > 내과학교실 > Articles
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