AMP-activated protein kinase 활성화 물질과 생체기능조절

Title
AMP-activated protein kinase 활성화 물질과 생체기능조절
Other Titles
AMP-activated protein kinase Activating Agent and Its Implication
Author(s)
최형철
Keywords
AMP-activated protein kinase; AMPK activating agent; LKB1
Issue Date
201206
Publisher
대한내분비학회
Citation
Endocrinology and Metabolism, v.27, no.2, pp.109 - 115
Abstract
AMP-activated protein kinase (AMPK) is an important cellular fuel sensor. Activation of AMPK requires phosphorylation at threonine (Thr)-172, which resides in the activation loop of the α1 and α2 subunits. Several AMPK upstream kinases are capable of phosphorylating AMPK at Thr-172, including LKB1 and CaMKKβ. AMPK has been implicated in the regulation of physiological signals,such as inhibition of cholesterol, fatty acid, protein synthesis, and enhancement of glucose uptake and blood flow. AMPK activation also exhibits several salutary effects on vascular function and improves vascular abnormalities. AMPK is activated by numerous drugs and xenobiotics. Some of these are in clinical use for the treatment of type 2 diabetes (e.g., metformin and thiazolidinediones),hypertension (e.g., nifedipine and losartan), and impaired blood flow (e.g., aspirin, statins, and cilostazol). Plant-derived xenobiotics or nutraceuticals that were claimed to have health benefits in diabetes or cancer have been reported to activate AMPK. These include resveratrol from red wine, epigallocatechin gallate from green tea, capsaicin from peppers, berberine, which is a yellow dye of the genus berberis, genistein from soy bean, and ginsenoside from ginseng panax. AMPK is also modulated by numerous hormones and cytokines that regulate energy balance at the whole body level, including leptin, adiponectin, ghrelin, and even thyroid hormones. This work shows that the precise mechanisms of AMPK kinase and AMPK interaction.
URI
http://hdl.handle.net/YU.REPOSITORY/27797
ISSN
2093-596X
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의과대학 > 약리학교실 > Articles
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