Porcine testicular extract inhibits T cell proliferation by blocking cell cycle transition from G(1) phase to S phase

Title
Porcine testicular extract inhibits T cell proliferation by blocking cell cycle transition from G(1) phase to S phase
Author(s)
최인호이한형[이한형]이석준[이석준]김선희[김선희]Manheum Na[Manheum Na]정선아[정선아]이동목전용필[전용필]이기호[이기호]전태훈[전태훈]
Keywords
SEX-HORMONES; IMMUNE-RESPONSE; AUTOIMMUNITY; ACTIVATION; HUMANS; ESTER
Issue Date
201207
Publisher
SPRINGER
Citation
BIOTECHNOLOGY LETTERS, v.34, no.7, pp.1225 - 1233
Abstract
Since T cells express diverse sex steroid hormone receptors, they might be a good model to evaluate the effects of sex steroid hormones on immune modulation. Porcine testicular extract contains several sex steroid hormones and may be useful to study the effects of sex steroid hormones during T cell activation. We have examined the effects of the porcine testicular extract on T cell activation: proliferation and secretion of cytokines (IL-2 and IFN-gamma) by activated T cells were severely decreased after treatment with porcine testicular extract. The extract produced an immunosuppressive effect and inhibited the proliferation of activated T cells by blocking the cell cycle transition from the G(1) phase to S phase. These effects were mediated by a decrease in the expression of cyclin D1 and cyclin E and constitutive expression of p27(KIP1) after T cell activation.
URI
http://hdl.handle.net/YU.REPOSITORY/27682http://dx.doi.org/10.1007/s10529-012-0907-6
ISSN
0141-5492
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생명공학부 > 생명공학부 > Articles
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