Toenail Selenium and Incidence of Type 2 Diabetes in U.S. Men and Women

Title
Toenail Selenium and Incidence of Type 2 Diabetes in U.S. Men and Women
Author(s)
박경Eric B. Rimm[Eric B. Rimm]David S. Siscovick[David S. Siscovick]Donna Spiegelman[Donna Spiegelman]JoAnn E. Manson[JoAnn E. Manson]J. Steven Morris[J. Steven Morris]Frank B. Hu[Frank B. Hu]Dariush Mozaffarian[Dariush Mozaffarian]
Keywords
CORONARY-HEART-DISEASE; OXIDATIVE STRESS; PHYSICAL-ACTIVITY; GLUTATHIONE-PEROXIDASE; INSULIN-RESISTANCE; GENE-EXPRESSION; RISK; MELLITUS; HUMANS; TRIAL
Issue Date
201207
Publisher
AMER DIABETES ASSOC
Citation
DIABETES CARE, v.35, no.7, pp.1544 - 1551
Abstract
OBJECTIVE-Compelling biological pathways suggest that selenium (Se) may lower onset of type 2 diabetes mellitus (T2DM), but very few studies have evaluated this relationship, with mixed results. We examined the association between toenail Se and incidence of T2DM. RESEARCH DESIGN AND METHODS-We performed prospective analyses in two separate U.S. cohorts, including 3,630 women and 3,535 men, who were free of prevalent T2DM and heart disease at baseline in 1982-1983 and 1986-1987, respectively. Toenail Se concentration was quantified using neutron activation analysis, and diabetes cases were identified by biennial questionnaires and confirmed by a detailed supplementary questionnaire. Hazard ratios of incident T2DM according to Se levels were calculated using Cox proportional hazards. RESULTS-During 142,550 person-years of follow-up through 2008, 780 cases of incident T2DM occurred. After multivariable adjustment, the risk of T2DM was lower across increasing quintiles of Se, with pooled relative risks across the two cohorts of 1.0 (reference), 0.91 (95% CI 0.73-1.14), 0.78 (0.62-0.99), 0.72 (0.57-0.91), and 0.76 (0.60-0.97), respectively (P for trend = 0.01). Results were similar excluding the few individuals (4%) who used Se supplements. In semiparametric analyses, the inverse relationship between Se levels and T2DM risk appeared to be linear. CONCLUSIONS-At dietary levels of intake, individuals with higher toenail Se levels are at lower risk for T2DM. Further research is required to determine whether varying results in this study versus prior trials relate to differences in dose, source, statistical power, residual confounding factors, or underlying population risk.
URI
http://hdl.handle.net/YU.REPOSITORY/27652http://dx.doi.org/10.2337/dc11-2136
ISSN
0149-5992
Appears in Collections:
생활과학대학 > 식품영양학과 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE