Evidence of Corticospinal Tract Injury at Midbrain in Patients With Subarachnoid Hemorrhage

Title
Evidence of Corticospinal Tract Injury at Midbrain in Patients With Subarachnoid Hemorrhage
Author(s)
장성호여상석최병연장철훈김성호정영진
Keywords
BRAIN
Issue Date
201208
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Citation
STROKE, v.43, no.8, pp.2239 - 2241
Abstract
Background and Purpose-Clear elucidation of the exact pathophysiological mechanisms of motor weakness in patients with subarachnoid hemorrhage has not yet been achieved. We attempted to investigate injury to the corticospinal tract in patients with subarachnoid hemorrhage using diffusion tensor imaging. Methods-Twenty-two patients with subarachnoid hemorrhage and 24 control subjects were recruited for this study. DTI-Studio software was used for reconstruction of the corticospinal tract. We measured fractional anisotropy and apparent diffusion coefficient values at 5 regions of interest along the corticospinal tract pathway including: the corona radiata, the posterior limb of the internal capsule, the upper midbrain, the midpons, and the upper medulla. Results-Fractional anisotropy value for the midbrain region of interest was lower in the patient group compared with the control group without change of apparent diffusion coefficient value (P < 0.05). By contrast, fractional anisotropy and apparent diffusion coefficient values of the other 4 regions of interest were not different between the patient and control groups. Conclusions-Injury of the corticospinal tract at the midbrain was observed in patients with subarachnoid hemorrhage. Injury of the corticospinal tract at the midbrain appears to be one of the various pathophysiological mechanisms for motor weakness after subarachnoid hemorrhage. (Stroke. 2012; 43: 2239-2241.)
URI
http://hdl.handle.net/YU.REPOSITORY/27575http://dx.doi.org/10.1161/STROKEAHA.112.661116
ISSN
0039-2499
Appears in Collections:
의과대학 > 재활의학교실 > Articles
의과대학 > 신경외과학교실 > Articles
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