Synthesis of benzo-annulated tryptanthrins and their biological properties

Title
Synthesis of benzo-annulated tryptanthrins and their biological properties
Author(s)
장영동량경록권영주[권영주]박소은[박소은]
Keywords
ISATIS-TINCTORIA; SIMPLE ALKALOIDS; RING-SYSTEM; DERIVATIVES; 2,3-POLYMETHYLENE-4(3H)-QUINAZOLINONES; IDENTIFICATION; PHARMACOPHORE; MECHANISM; PRODUCTS; ANALOGS
Issue Date
201208
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
BIOORGANIC & MEDICINAL CHEMISTRY, v.20, no.16, pp.4962 - 4967
Abstract
A series of benzo-annulated derivatives of tryptanthrin were prepared and their optical and redox properties were studied. Tryptanthrin and its benzo-annulated derivatives showed selective inhibitory activity on topo I with an increase of activity on topo II by benzo-annulation on quinazolin-4(3H)-one moiety. Although the benzo-annulation on quinazolin-4(3H)-one ring did not affect significantly on the inhibitory activities against topo I and II, the benzoannulation on indolin-3-one ring affected the inhibitory activity very much especially by linear annulation. Cytotoxicities were not significantly changed upon benzoannulation, which were not directly related either to the inhibitory activities against topo I and II or to the reduction potentials. (C) 2012 Elsevier Ltd. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/27570http://dx.doi.org/10.1016/j.bmc.2012.06.034
ISSN
0968-0896
Appears in Collections:
약학대학 > 약학부 > Articles
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