Outcomes After Unrestricted Use of Everolimus-Eluting and Sirolimus-Eluting Stents in Routine Clinical Practice A Multicenter, Prospective Cohort Study

Title
Outcomes After Unrestricted Use of Everolimus-Eluting and Sirolimus-Eluting Stents in Routine Clinical Practice A Multicenter, Prospective Cohort Study
Author(s)
박종선박덕우[박덕우]김영학[김영학]송해근[송해근]이종영[이종영]김원장[김원장]강수진[강수진]이승환[이승환]이철환[이철환]박승정[박승정]박성욱[박성욱]허성호[허성호]허승호[허승호]
Keywords
CORONARY-ARTERY-DISEASE; BARE-METAL STENTS; RANDOMIZED-TRIALS; REVASCULARIZATION; METAANALYSIS; THROMBOSIS; EFFICACY; SAFETY
Issue Date
201208
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Citation
CIRCULATION-CARDIOVASCULAR INTERVENTIONS, v.5, no.3, pp.365 - 371
Abstract
Background-It remains unclear whether there are differences in the safety and efficacy outcomes between everolimus-eluting stents (EES) and sirolimus- eluting stents (SES) in contemporary practice. Methods and Results-We prospectively enrolled 6166 consecutive patients who received EES (3081 patients) and SES (3085 patients) between April 2008 and June 2010, using data from the Interventional Cardiology Research In-Cooperation Society-Drug-Eluting Stents Registry. The primary end point was a composite of death, nonfatal myocardial infarction (MI), or target-vessel revascularization (TVR). At 2 years of follow-up, the 2 study groups did not differ significantly in crude risk of the primary end point (12.1% for EES versus 12.4% for SES; HR, 0.97; 95% CI, 0.84-1.12, P=0.66). After adjustment for differences in baseline risk factors, the adjusted risk for the primary end point remained similar for the 2 stent types (HR, 0.96; 95% CI, 0.82-1.12, P=0.60). There were also no differences between the stent groups in the adjusted risks of the individual component of death (HR, 0.93; 95% CI, 0.67-1.30, P=0.68), MI (HR, 0.97; 95% CI, 0.79-1.18, P=0.74), and TVR (HR, 1.10; 95% CI, 0.82-1.49, P=0.51). The adjusted risk of stent thrombosis also was similar (HR, 1.16; 95% CI, 0.47-2.84, P=0.75). Conclusions-In contemporary practice of percutaneous coronary intervention procedures, the unrestricted use of EES and SES showed similar rates of safety and efficacy outcomes with regard to death, MI, sent thrombosis, and TVR. Future longer-term follow-up is needed to better define the relative benefits of these drug-eluting stents.
URI
http://hdl.handle.net/YU.REPOSITORY/27518http://dx.doi.org/10.1161/CIRCINTERVENTIONS.111.966549
ISSN
1941-7640
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의과대학 > 내과학교실 > Articles
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