Detectability of low and intermediate or high risk prostate cancer with combined T2-weighted and diffusion-weighted MRI

Title
Detectability of low and intermediate or high risk prostate cancer with combined T2-weighted and diffusion-weighted MRI
Author(s)
고영휘Sung, Deuk Jae[Sung, Deuk Jae]Doo, Kyung Won[Doo, Kyung Won]Park, Beom Jin[Park, Beom Jin]Kim, Min Ju[Kim, Min Ju]Cho, Sung Bum[Cho, Sung Bum]Oh, Yu Whan[Oh, Yu Whan]Yang, Kyung Sook[Yang, Kyung Sook]
Keywords
CONTRAST-ENHANCED MRI; GLEASON SCORE; RADICAL PROSTATECTOMY; ACTIVE SURVEILLANCE; COEFFICIENT MAP; TUMOR-DETECTION; 3 T; BIOPSY; TISSUE; HISTOPATHOLOGY
Issue Date
201208
Publisher
SPRINGER
Citation
EUROPEAN RADIOLOGY, v.22, no.8, pp.1812 - 1819
Abstract
To evaluate the incremental value of diffusion-weighted imaging (DWI) in combination with T2-weighted imaging to detect low (Gleason score, a parts per thousand currency sign 6) and intermediate or high risk (Gleason score, a parts per thousand yen 7) prostate cancer. Fifty-one patients who underwent MRI before prostatectomy were evaluated. Two readers independently scored the probability of tumour in eight regions of prostate on T2-weighted images (T2WI) and T2WI combined with apparent diffusion coefficient (ADC) maps. Data were divided into two groups-low risk and intermediate or high risk prostate cancer-and correlated with histopathological results. Diagnostic performance parameters, areas under the receiver-operating characteristic curve (AUCs) and interreader agreement were calculated. For both readers, AUCs of combined T2WI and ADC maps were greater than those of T2WI in intermediate or high risk (reader 1, 0.887 vs. 0.859; reader 2, 0.732 vs 0.662, P < 0.05) prostate cancers, but not in low risk (reader 1, 0.719 vs 0.725; reader 2, 0.685 vs. 0.680, P > 0.05) prostate cancers. Weighted kappa value of combined T2WI and ADC maps was 0.689. The addition of DWI to T2-weighted imaging improves the accuracy of detecting intermediate or high risk prostate cancers, but not for low risk prostate cancer detection. aEuro cent Gleason scores influence diagnostic performance of MRI for prostate cancer detection. aEuro cent Addition of DWI does not improve low risk prostate cancer detection. aEuro cent Combined T2WI and DWI may help select intermediate or high risk patients.
URI
http://hdl.handle.net/YU.REPOSITORY/27493http://dx.doi.org/10.1007/s00330-012-2430-5
ISSN
0938-7994
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의과대학 > 비뇨기과학교실 > Articles
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