The coffee diterpene kahweol inhibits metastasis by modulating expressions of MMPs and VEGF via STAT3 inactivation

Title
The coffee diterpene kahweol inhibits metastasis by modulating expressions of MMPs and VEGF via STAT3 inactivation
Author(s)
김형균[김형균]황용필[황용필]한은희[한은희]최재호[최재호]권광일[권광일]정용철[정용철]정명호[정명호]정태천강원구정혜광[정혜광]
Keywords
ENDOTHELIAL-GROWTH-FACTOR; MATRIX METALLOPROTEINASE-2; SIGNAL TRANSDUCERS; CANCER; CELLS; ANGIOGENESIS; CONSUMPTION; CAFESTOL; INVASION; TARGET
Issue Date
201208
Publisher
ELSEVIER SCI LTD
Citation
FOOD CHEMISTRY, v.133, no.4, pp.1521 - 1529
Abstract
Kahweol, a coffee-specific diterpene, is reported to have anti-cancer properties, although its precise chemopreventive mechanism remains unclear. The aim of our study was to determine the effect of kahweol on anti-metastatic activities and the possible mechanisms. Kahweol inhibited the migration and invasion ability of various cancer cells in vitro and decreased the secretion of metalloproteinase (MMP)-2, MMP-9, and VEGF in cancer cells via suppression of STAT3 activation. Kahweol also exhibited an inhibitory effect on lung metastasis in the experimental B16-F10 melanoma metastasis model. Moreover, kahweol inhibited migration and tube formation of endothelial cells in vitro, decreased the secretion of VEGF, and suppressed neovascularisation in Matrigel plugs in mice. Our findings demonstrate that kahweol inhibits metastasis through the disruption of STAT3-mediated transcription of the MMP and VEGF genes. (C) 2012 Elsevier Ltd. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/27477http://dx.doi.org/10.1016/j.foodchem.2012.02.043
ISSN
0308-8146
Appears in Collections:
약학대학 > 약학부 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE